Conjugate addition of organocopper reagents to ct,-ethylenic aldehydes is discussed. Use of cz,r3-ethylenic aminals is an— other approach to the same target, namely homologation of R-M to an aldehyde with three more carbon atoms. The c,-ethylenic aldehydes are easily prepared by carbocupration of c,13-acetylenic acetals. A new way to cz,t3-ethylenic ketones, mediated by organo copper reagents i...

Lithium organoamidocuprates of the general stoichiometry LiCuR(NR) are an important class of organocopper reagents and have found widespread application in conjugate addition and other bond-forming reactions. The dependence of the structures and equilibrium of these species on the steric and electronic properties of the amido group is reported in both the solid state and in solution. Three diff...

Alkynes may be regioselectively alkylated to alkenes by organocopper reagents in a reaction known as “carbocupration”, where an alkylCu(I) binds the alkyne and transfers its organic moiety one of carbon atoms. hetero-substituted with third-row elements yield regiochemistry opposite that obtained when using alkynes second-row elements. Early computational investigations his mechanism have identi...

Fatty acid esters have been synthesized in good yield by reaction between copper(I) ate complexes formed from methylcopper(I) and primary or secondary Grignard reagents and esters of primary iodoalkylcarboxylic acids. The synthetic method is i l lustrated with proced.ures for CHr:gH(CHz)rgCO2C2H5, CeHsCHzO(CH2)16COzCzHs, CH3(CH2)25CO2C2H5, CH3O2C(CH)I2CO2CHI, CzHsOzC(CHz)szCO2C2H5, and CHg(CH2)...

An access to copper(0) nanoparticles (CuNPs) from readily available organocopper reagents is reported. This original amine-free methodology proves be practical, fast, and highly reproducible. It yields spherical CuNPs with an excellent control of their size shape. These are fully characterized by electronic microscopy (transmission electron high-resolution TEM), X-ray photoelectron spectroscopy...