One of the major problems met for the conception of antiviral or antiparasitic drugs is to reach a high level of selectivity towards the pathogenic agent versus the host. We shall describe two synthetic approaches where main group organometallics have been used towards this goal. A series of nucleoside sila-analogues was synthesized as potential therapeutic agents designed to inhibit HIV Revers...

unique status among methods for the construction of carbon– carbon bonds. The well-established Stille–Migita–Kosugi coupling of organostannanes and the Suzuki–Miyaura coupling of organoboron compounds are two reactions that, until recently, have been the “gold-standard” among various palladium-catalyzed coupling reactions. Their wide use and extraordinary synthetic utility have provided the imp...