Taste function requires neural circuits to transmit gustatory information from taste receptor cells in taste buds, via afferent nerves to the soma of ganglion neurons, and through central ganglion processes into the brainstem. During initial formation, the sensory ganglion neurons have a key situation in establishing receptive fields by extending neurites bidirectionally, to the peripheral tast...

Pitx2 is a homeodomain transcription factor that is mutated in Rieger syndrome, a haploinsufficiency disorder affecting eyes and teeth. Pitx2 also has a postulated role in left-right axis determination. We assessed the requirements for Pitx2 directly by generating hypomorphic and null alleles. Heterozygotes for either allele have eye abnormalities consistent with Rieger syndrome. The ventral bo...

although lightning is an uncommon phenomenon in nature; it can cause many destructive incidents. in the event of a lightning strike, multiple organs particularly the cardiovascular systems are at risk of injury. short-term mortality depends on its cardiac effects. in this paper, the authors report the development of myocardial infarction and pericardial effusion after lightning injury, a typica...

Experiments are described in which the development of the gravity-sensing organs was studied in newt larvae reared in microgravity on the IML-2 mission and in Aplysia embryos and larvae reared on a centrifuge at 1 to 5 g. In Aplysia embryos, the statolith (single dense mass on which gravity and linear acceleration act) was reduced in size in a graded fashion at increasing g. In early post-metam...

The girdle epidermis of adult Mopalia muscosa secretes several types of structures, including calcareous spicules and innervated hairs. Newly metamorphosed chitons superficially resemble adult animals, but they lack the adult girdle ornaments, shell sculpture, and coloration. The morphogenesis of the adult girdle structures has not been described previously for any species. Juvenile Mopalia mus...

Masumi Umezawa Futaro Ebina Yusuke Fujii Koji Matsuda Kazuo Hiramoto Kikuo Umegaki, Ph.D. Hiroki Shirato, M.D., Ph.D. OVERVIEW: The use of particle beams in treating cancer, both in Japan and overseas, is growing in recognition of their ability to precisely target the dose of radiation on the cancerous tumor while minimizing the impact on surrounding organs. In particular, it is anticipated tha...

The blood vasculature regulates both the development and function of secondary lymphoid organs by providing a portal for entry of hemopoietic cells. During the development of lymphoid organs in the embryo, blood vessels deliver lymphoid tissue inducer cells that initiate and sustain the development of lymphoid tissues. In adults, the blood vessels are structurally distinct from those in other o...

this study  Evaluation the physiological activity effects of thyroid glands on the process of development and growth of ovaries and reproductive organs in rats.the study also investigates the adverse effects of antithyroid compounds adminidtered to mothers during lactation period on the developmental process of the newborn rat,s reproductive organs and the level of sexual hormones.the early and...