We identify three properties of the standard oncology Phase I trial design or 3 + 3 design. We show that the standard design implicitly uses isotonic regression to estimate a maximum tolerated dose. We next illustrate the relationship between the standard design and a Bayesian design proposed by Ji et al. (2007). A slight modification to this Bayesian design, under a particular model specificat...

OBJECTIVE Written asthma management plans (WAMPs) for patients constitute a key component of current national asthma guidelines, but it is not known whether these plans meet the readability standards (of fifth-grade level or lower) recommended by health education experts. The objective of this study was to assess whether WAMPs presented in national guidelines are written at or below a fifth-gra...

We examined the relationship between perceived workload and performance by evaluating the responses of police officers to 4 different draw-and-shoot tasks in a night field training exercise which was part of their regular training regimen. Sixty-two police officers volunteered to participate. Results demonstrated an associative trend among 3 tasks where shooting performance decreased and worklo...

This study examined 3 factors that were hypothesized to increase risk for aggression among urban children: economic disadvantage, stressful events, and individual beliefs. Participants were 1,935 African American, Hispanic, and White elementary-school boys and girls assessed over a 2-year period. The relation between individual poverty and aggression was only significant for the White children,...

Children between 7 and 8 years old took part in a staged event at school and 1 week later were assessed using a short form of the Wechsler Intelligence scale for children (third edition) and measures of metamemory, narrative ability, and socioeconomic status. Two weeks following the event, children either received narrative elaboration training (NET; K.J. Saywitz & L. Snyder, 1996) and were pro...

The connection between adolescent dating violence (ADV) and substance use is important to consider because of the serious consequences for teens who engage in these behaviors. Although prior research shows that these two health problems are related, the context in which they occur is missing, including when (i.e., the timeline) in the relationship these events occur. To fill this gap, eight sex...

The present report is one of the results from the pre-study “Leksaker blir lärsaker”, completed in March 2003. It is complemented by the report “Lekfullt lärande: Spel och simuleringar i lärandesyfte (Playful learning: Games and simulations with a learning objective)” (Harvard, 2003), including interviews with people having practical experience from play-related design of learning environments....

Considered biologically as well as philosophically, man is a most singular product of the evolutionary process. He receives and transmits not one but two heredities, the biological and the cultural. Man’s biological heredity is very much like that of any other organism; it is transmitted solely from parents to their children, and to other direct descendants. Cultural heredity, or simply culture...

For a compact Riemannian manifold (M, g) with boundary and dimension n, with n ≥ 2, we study the existence of metrics in the conformal class of g with scalar curvature Rg and mean curvature hg on the boundary. In this paper we find sufficient and necessary conditions for the existence of a smaller metric g̃ < g with curvatures Rg̃ = Rg and hg̃ = hg. Furthermore, we establish the uniqueness of such...

BACKGROUND Much work has investigated the association between substance use, crime, and recidivism, yet little scholarship has examined these associations longitudinally among samples of recently released prisoners. We examine the lagged reciprocal effects of hard substance use and crime, among other covariates, in the context of the prisoner reentry process. METHODS We rely on data from the ...