Ovarian failure leading to infertility can be caused by improper prenatal development of the fetal gonad or disruption of the complex postnatal process of folliculogenesis due to alterations in intragonadal or extragonadal regulation. It is critical to have physiological models that mimic events occurring during human development to understand, treat, and prevent ovarian failure in women. Many ...

Ovarian follicular development in the species follows a wave dynamics involving mostly 2wave or 3-wave cycles. Although there are still large gaps in our understanding of the etiopathogenic mechanisms underlying reproductive disorders in buffalo, available literature suggests alterations in ovarian dynamics at one or more stages of follicular development. This article gives a brief account of t...

Adverse drug reactions (ADRs) are a major problem in drug therapy and drug development. Inter-individual genetic differences can have significant roles in determining an individual’s susceptibility to ADRs. The rapid development of techniques in the area of genome analysis has put the scientific community in a power position and facilitated identification of new pharmacogenomic biomarkers that ...

Background: The physiological age of vectors is an indicator often used in the evaluation of the efficacy of malaria vector means. The purpose is to study the ovarian development stage for the determination of the physiological age of mosquitoes. Methods: Mosquitoes were collected using human landing catch at night in the district of Itassoumba and Abomey-takplikpo, south-eastern Benin. Females...

.......................................................................................... xiv Research Publications ................................................................... xviii Conference abstracts ..................................................................... xix Chapter 1: Introduction ..................................................................... 2 1.1 Folliculoge...

Advances in assisted reproduction techniques and the treatment of diseases known to be correlated with infertility such as polycystic ovary syndrome and premature ovarian failure require a better understanding of ovarian physiology. Despite the enormous quantity of information produced over the last two decades, the mechanisms controlling follicular development are not fully understood. Ovarian...

background: the ability of the ovary to respond to exogenous gonadotrophin stimulation and development of several follicles is essential in assisted reproductive technology. neither age and regularity of menses nor follicular phase fsh and estradiol concentrations are reliable predictors of ovarian response. day 3 serum inhibin-b level, during induction ovulation, has been proposed as a predict...

Molecular events leading to epithelial ovarian cancer are poorly understood but ovulatory hormones and a high number of life-time ovulations with concomitant proliferation, apoptosis, and inflammation, increases risk. We identified genes that are regulated during the estrous cycle in murine ovarian surface epithelium and analysed these profiles to identify genes dysregulated in human ovarian ca...

Background: Polycystic Ovarian Syndrome (PCOS) is a pro-inflammatory condition that supports the development of metabolic aberration and ovarian dysfunction. Chronic inflammation and the increased levels of androgens in this group of patients and their impact on the immune system may increase the risk of developing malignancies, including ovarian cancer. Thus, we interacted ovarian tumor cells ...

background: this study aimed to assess follicle survival after xenotransplantation of sheep ovarian tissue into male and female immunodeficient rats. we evaluated the effects of gonadotropin treatment on follicular development in the transplanted tissue. materials and methods: in this experimental study, sheep ovarian cortical strips were transplanted into the neck back muscles of 8 male and 8 ...