Iris Borowy (ed.), Uneasy encounters: the politics of medicine and health in China 1900–1937, Frankfurt am Main and Oxford, Peter Lang, 2009, pp. 230, £40.00 (paperback 978-3-631-57803-2). Iris Bruijn, Ship’s surgeons of the Dutch East India Company: commerce and the progress of medicine in the eighteenth century, Leiden University Press, 2009, pp. 388, illus., e39.50 (paperback 978-90-87-28-05...

functions. However, the mechanisms of GABAergic neurogenesis in the midbrain are not well understood. Previously, it has been shown that Ascl1 is required for development of GABAergic neurons in the midbrain. Here we have characterized in more detail the role of Ascl1 in the development of distinct subpopulations of midbrain GABAergic neurons. In Ascl1-null mutants GABAergic neurons are complet...

The cellular role of protein kinases (PKs) have been studied extensively, but relatively little is known as to how specific expression of PKs mediate early development and differentiation. We have used directed differentiation of ES cells towards the mesendodermal lineage in combination with microarray analysis to identify a set of PKs that are induced upon differentiation from the pluripotent ...

cilia. At E9.5, B9D1 is expressed throughout the spinal cord, limb bubs, and, bronchial arches; tissues that required Shh signal for proper development. To further understand its molecular mechanism, we sought out other interacting proteins using tandem IP followed by mass spec analysis. A protein complex is identified and one of them was a transmembrane protein BCAP1 (B9 Complex Associated Pro...

Amphibian holoblastic cleavage in which all blastomeres contribute to any one of the three primary germ layers has been widely thought to be a developmental pattern in the stem lineage of vertebrates, and meroblastic cleavage to have evolved independently in each vertebrate lineage. In extant primitive vertebrates, agnathan lamprey and basal bony fishes also undergo holoblastic cleavage, and th...

Geoffrey Davenport, Ian McDonald and Caroline Moss-Gibbons, The Royal College of Physicians and its collections: an illustrated history, London, Royal College of Physicians, 2001, pp. 168, illus., UK £38.00, overseas £45.00 (hardback 0-907-383-831). Michael Dunnill, The Plato of Praed Street: the life and times of Almroth Wright, London, Royal Society of Medicine Press, 2000, pp. xiii, 269, ill...