نتایج جستجو برای: p67
تعداد نتایج: 459 فیلتر نتایج به سال:
A temperature-sensitive mutant nuc2-663 of the fission yeast Schizosaccharomyces pombe specifically blocks mitotic spindle elongation at restrictive temperature so that nuclei in arrested cells contain a short uniform spindle (approximately 3-micron long), which runs through a metaphase plate-like structure consisting of three condensed chromosomes. In the wild-type or in the mutant cells at pe...
A temperature-sensitive mutant nuc2-663 of the fission yeast Schizosaccharomyces pombe specifically blocks mitotic spindle elongation at restrictive temperature so that nuclei in arrested cells contain a short uniform spindle ('~3-I.tm long), which runs through a metaphase plate-like structure consisting of three condensed chromosomes. In the wild-type or in the mutant cells at permissive tempe...
in an attempt to characterize theileria parva parasites circulating in south sudan cattle , polymerase chain reaction (pcr)-based assays were carried out using four single copy encoding antigen genes p104, pim, p150 and p67 in addition to one microsatellite ms321. a total of 20 bovine dna samples from two locations in south sudan were included in this study, in addition to two references strain...
Salehpour F, Ghanian Z, Yang C, Zheleznova NN, Kurth T, Dash RK, Cowley AW Jr, Ranji M. Effects of p67 on the mitochondrial oxidative state in the kidney of Dahl salt-sensitive rats: optical fluorescence 3-D cryoimaging. Am J Physiol Renal Physiol 309: F377–F382, 2015. First published June 10, 2015; doi:10.1152/ajprenal.00098.2015.—The goal of the present study was to quantify and correlate the...
The superoxide-forming nicotinamide adenine dinucleotide phosphate reduced (NADPH) oxidase of human phagocytes comprises membrane-bound and cytosolic proteins, which, upon cell activation, assemble on the plasma membrane to form the active enzyme. Patients with chronic granulomatous disease (CGD) are defective in one of the phagocyte oxidase (phox) components, p47-phox or p67-phox, which reside...
The cytosolic 67-kD protein in phagocytes (p67-phox) and B lymphocytes is one of essential components of the superoxide-generating system in these cells, and its defect causes an autosomal recessive type of chronic granulomatous disease (CGD). We performed mutation analysis of p67-phox mRNA from a CGD patient who lacks the protein and found an in-frame deletion from nucleotide 694 to 879, which...
The cytosolic NADPH oxidase cofactor p67 has been shown to be one of the limiting factors in assembly and activation of this multiprotein enzyme complex and, therefore, must be highly regulated at the transcriptional level. In the present studies, we have further characterized the promoter for human p67. Genomic sequence upstream of the translational start site (TLS; 2 kb) was cloned, and RACE ...
The phagocyte-type NADPH oxidase expressed in endothelial cells differs from the neutrophil enzyme in that it exhibits low level activity even in the absence of agonist stimulation, and it generates intracellular reactive oxygen species. The mechanisms underlying these differences are unknown. We studied the subcellular location of (a) oxidase subunits and (b) functionally active enzyme in unst...
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