This article introduces a cascaded packed U cell (CPUC) multilevel converter (MLC) to achieve higher-level count in voltage with minimum number of switches. Here, two five-level topologies are connected manner obtain 25 levels its output voltage. The switch CPUC is reduced 12, as compared the semiconductor devices used for obtaining output. A binary-quintuple progression selection ratios betwee...

This paper presents a novel methodology for the design of Space Vector (SV) switching sequences in order to reduce output voltage distortion and common-mode (CMV) without increasing number commutations comparison conventional optimised techniques presented literature. Three spaces can be distinguished converter, referring to: line-to-line voltages, phase voltages states. Consequently, three cor...

Regular packed cell transfusion in patients with thalassemia major leads to iron overload. Chelation therapy is one of the important aspects of thalassemia care as iron overload causes significant cardiac, hepatic, and endocrine dysfunction. We report a case of thalassemia major with severe iron overload causing cardiac and liver dysfunction who benefitted from triple drug chelation therapy. Tr...

To reach cancer cells in optimal quantities, therapeutic agents must be delivered to tumors through their imperfect blood vascular system, cross vessel walls into the interstitium, and penetrate multiple layers of tissue. Strategies to enhance drug penetration have potential to improve therapeutic outcome. The development of multicellular layers (MCLs), in which tumor cells are grown on a semip...

BACKGROUND In higher plant cells, lignin provides necessary physical support for plant growth and resistance to attack by microorganisms. For the same reason, lignin is considered to be a major impediment to the process of deconstructing biomass to simple sugars by hydrolytic enzymes. The in situ variation of lignin in plant cell walls is important for better understanding of the roles lignin p...

BACKGROUND The leading cause of late mortality after trauma is multiple organ failure syndrome, due to a dysfunctional inflammatory response early after injury. Preclinical studies demonstrate that hypertonicity alters the activation of inflammatory cells, leading to reduction in organ injury. The purpose of this study was to evaluate the effect of hypertonicity on organ injury after blunt trau...

INTRODUCTION Blood transfusion is associated with increased morbidity and mortality. We developed and implemented an algorithm for coagulation management in cardiovascular surgery based on first-line administration of coagulation factor concentrates combined with point-of-care thromboelastometry/impedance aggregometry. METHODS In a retrospective cohort study including 3,865 patients, we analy...

Previous studies have found that there is a correlation between mothers' haemoglobin concentration or packed cell volume and infants' birth weight, and that iron supplementation increases mothers' haemoglobin concentration. The purpose of this study, using the data of a large randomised trial on iron prophylaxis during pregnancy, was to find out whether iron supplementation causes fetal growth ...

Background: It is not clear whether the use of volumetric peristaltic infusion pumps, affect the quality of the erythrocytes during packed cell transfusion or not. In the present study in vitro quality of red blood cells was assessed after using this type of infusion pumps in a prospective study. Materials and Methods: In this study 60 units of packed red cells were examined before and after p...