A patient is described who presented with a 10 year history of intermittent peptic ulcer symptoms and a 3 year history of an undiagnosed skin rash. Investigations indicated raised plasma levels of gastrin, glucagon and pancreatic polypeptide. A single tumour was localised to the pancreas and resected. The tumour had the typical histology of an apudoma, and contained cells which stained for gast...

Endosonography was carried out in a patient with an extensive juxtapapillary tumour. Radiology and endoscopy were unable to distinguish a villous adenoma from an invasive carcinoma. Endosonography revealed a mucosal hypoechoic tumour without penetration into the submucosa and muscularis propria. The common bile duct, pancreatic duct, and pancreas were normal. Lymph node abnormalities were not f...

While regional heterogeneity in islet distribution has been well studied in rodents, less is known about human pancreatic histology. To fill gaps in our understanding, regional differences in the adult human pancreas were quantitatively analyzed including the pathogenesis of type 2 diabetes (T2D). Cadaveric pancreas specimens were collected from the head, body and tail regions of each donor, in...

Treatment with mesenchyme stem cells (MSCs) plays a significant role in the therapies of many diseases such as diabetics. Vitamin D development insulin and can increase action sensitivity peripheral tissues. Moreover, there is limited research concerning mechanism therapeutic MSCs combination vitamin (vit. D). Therefore, we evaluated effect MSC intervention diabetic animal model. Diabetes was i...

The WHO categorizes the breast tumors in various distinct histological types based on cell morphology and architecture. A widely accepted fact that aggressive nature of cancer can be determined by its type, grade, nodal status, metastasis holds ground even era immunohistochemistry (IHC) molecular. An extremely rare variant primary carcinoma belongs to family mucin producing sharing same histolo...

CONTEXT Paragangliomas are rare tumours of neural crest origin. Extra-adrenal pancreatic paragangliomas are exceptionally rare. CASE REPORT A 66-year-old man with abdominal pain was noted to have a complex pancreatic head and uncinate process mass on imaging. He underwent complete resection by pancreaticoduodenectomy with final pathology confirming a 6 cm paraganglioma without evidence of met...

Diabetes mellitus is growing in prevalence worldwide. Uncontrolled industrialization has released heavy metal pollutants and toxic agents that may play a role in the islet function and development of diabetes mellitus. Among the toxic metals, chromium (Cr) is widely used in industries and is considered a major cause of environmental pollution. Cr (III) constitutes an essential nutrient, while C...

CONTEXT Ectopic pancreatic rest is an uncommon condition resulting in diverse clinical and pathological presentation. It results from altered development of two primitive pancreatic buds that fuse to form the uncinate-head and body-tail of normal gland. Ectopic pancreas is an anomaly where an ectopic rest develops at a place away from the normal site. CASE REPORT We describe a 48-year-old mal...

BACKGROUND A solid pseudopapillary tumour of the pancreas (SPTP) is a rare neoplasm. AIM We herein present five cases of SPTP diagnosed using endoscopic ultrasound (EUS) guided fine-needle biopsy (FNB) using a needle with side fenestration (ProCore-needle). METHODS From January 2011 to June 2012 in five patients with SPTP tissue acquisition was carried out with a 19-gauge (4 patients) or a ...