Intracellular activation of pancreatic digestive enzymes by lysosomal hydrolases is thought to be an early event in the pathogenesis of pancreatic injury. As ethanol excess is an important association of pancreatitis, experimental work has been directed towards exploring possible mechanisms whereby ethanol may facilitate contact between inactive digestive enzyme precursors and lysosomal enzymes...

GOAL To compare, during strong acid inhibition with omeprazole, the effect of 2 different doses of an enteric-coated pancreatic enzyme preparation on fecal fat excretion and abdominal symptoms in patients with exocrine insufficiency due to chronic pancreatitis (CP). BACKGROUND Treatment with pancreatic enzymes reduces fecal fat excretion in patients with CP but is rather unsuccessful due to i...

OBJECTIVES The gold standard for the diagnosis of fat malabsorption, the 72-hour fat balance study, requires a 3-day collection to generate a coefficient of fat absorption (CFA). We hypothesized that a new test using behenic acid (behenate test) as a nonabsorbable lipid marker may provide a facile means to assess fat absorption. The study proposed to answer 2 questions: first, whether the behen...

The purpose of this study is to determine the relationship between enzymatic antioxidants such as glutathione reductase and s-transferase prolidase adenosine deaminase in patients diagnosed with pancreatic cancer. Prolidase, deaminase, activities were determined spectrophotometrically blood sera collected from healthy control subjects included study. In cancer, mean value enzymes decreased, whi...

A trial of gemcitabine versus pancreatic enzymes for the treatment of pancreatic cancer reported an average survival time of 14 months for the chemotherapy group and 4.3 months for the enzyme group. Due to extensive missing information, readers of the paper reporting the trial would conclude that the study was valid. When this missing information is made available, as it is in the present repor...