Reactive hemophagocytic syndrome is clinically characterized by fever, hepatosplenomegaly, pancytopenia, and coagulopathy, and is histologically characterized by excessive proliferation and activation of histiocytes or macrophages. It can occur with systemic infections, immunodeficiency, or underlying malignancy. Brucellosis is one of the rare causes of hemophagocytosis. Herein we report an 11-...

Pancytopenia can rarely complicate Grave's disease. It can be due to uncontrolled thyrotoxicosis or as a result of rare side effect of antithyroid medication. Pernicious anemia leading to Vitamin B12 deficiency is another rare associated cause. We report a case of a patient with Grave's disease and undiagnosed pernicious anemia whom was assumed to have antithyroid drug induced pancytopenia. Fai...

Pancytopenia is an important hematological problem encountered in our day-to-day clinical practice. It is a decrease in all three cellular elements of peripheral blood leading to anemia, 1 leucopenia and thrombocytopenia . Pancytopenia usually presents with symptoms of bone marrow failure such as pallor, dyspnea, bleeding, bruising 2 and increased tendency to infections . The laboratory diagnos...

Background: Pancytopenia is an important clinico-hematological entity encountered in our day to day practice from a number of disease processes primarily and secondarily involving bone marrow (1,2). The severity of pancytopenia and the underlying pathology determine the management and prognosis of the patients (3). The present study has been undertaken to evaluate the various causes and to corr...

Brucellosis, a zoonotic infection, constitutes a major health and economic problem in many parts of the world, including countries of the Mediterranean Basin, The Middle East and The Arabian Gulf. Hematological complications in brucellosis are common and can be multi-factorial due to the pathogen's tropism for central (bone marrow) and peripheral (spleen) organs of the reticuloendothelial syste...

A case of salmonella paratyphi A fever with reversible pancytopenia in a 15 years old boy who presented with history of high grade continuous fever, epistaxis and haemoptysis, relative bradycardia and splenomegaly is described here. A brief review of the literature on possible causes of reversible pancytopenia in this case is also discussed.

Pancytopenia after intramuscular iron-dextran treatment occurred in an infant with Down's syndrome. Haematological abnormalities recurred on subsequent challenge. Positive migration inhibiting factor and mast cell degranulation tests support an allergic pathogenesis for the pancytopenia. These side effects have not been reported previously.

oral surgery in patients with bleeding disorders is associated with a high risk of bleeding during and after surgery. this article is aimed to present the case of an eight-year-old girl suffering from severe fanconi anemia with pancytopenia who underwent a dental extraction. the hemostatic effect of local administration of tranexamic acid in combination with a primary suture seems to be extreme...