Hepatoprotective drugs are not available for use in modern medicine and different parts of medicinal plants like Neem (Azadirachta indica) used as hepatoprotectants traditional medicine. Although there scientific reports its hepatoprotective activity on acute administration, we found only one study which had evaluated effect chronic administration. Objectives: To evaluate the oral administratio...

The hepatoprotective properties of Alchornea cordifolia, a medicinal plant was studied in hepatotoxicity induced animal model with high dose paracetamol or carbon tetrachloride. Knowing that antituberculosis drugs also represent risk factor for hepatotoxicity, could A. cordifolia play key role to limit their hepatotoxicity? objective this study assess the histological changes rat livers and evo...

Background & Aim: The human body has the liver as one of its largest organs. It serves as the major site for metabolism and excretion. Injury to the liver or impairment of its functions may complicate one’s health and therefore, constitutes one of the serious public health challenges. The ethanol seed extract of Citrus paradisi Macfad (CPE) was carried out to evaluate ...

BACKGROUND The genus Amaranthus has potential activity as a hepatoprotective agent. OBJECTIVE The present pharmacological investigation focuses on evaluation of the efficacy of aqueous extract of roots of Amaranthus tricolor Linn. for their protection against paracetamol (PCM) overdose induced hepatotoxicity. MATERIALS AND METHODS The aqueous extract of roots of A. tricolor Linn. was prepar...

BACKGROUND Melastoma malabathricum L. (Melastomaceae) is a small shrub with various medicinal uses. The present study was carried out to determine the hepatoprotective activity of methanol extract of M. malabathricum leaves (MEMM) against the paracetamol-induced liver toxicity in rats model. METHODS The respective chemicals and herbal solutions (10% DMSO, 200 mg/kg silymarin or MEMM (50, 250 ...

CONTEXT There is contention over whether reported dose correlates with toxicity in paracetamol poisoning and risk assessment is currently based on serum paracetamol concentration compared to a nomogram, irrespective of reported dose. Objective. To determine if reported dose predicts the need for N-acetylcysteine (NAC). METHODS Data were taken from paracetamol overdoses presenting to a tertiar...

Natural remedies from medicinal plants are considered to be effective and safe alternative treatment for liver injury.The present study was conducted to evaluate the hepatoprotective activity of aqueous ethanolic extract of aerial parts of Basella rubra in wistar rats. The studies were conducted using the two popular inducing agents Paracetamol (2gm/kg,p.o.) in 1% CMC and Carbon tetrachloride (...