OBJECTIVES/HYPOTHESIS Sulcus vocalis is an epithelial invagination adherent to deep tissues of the vocal fold. Traditionally, dysphonia is believed to result from attenuation or absence of lamina propria and consequent alteration of mucosal dynamics. This conception does not account for several clinical features of the lesion, most notably inflammation. The goal of this study is to elucidate th...

Topical glucocorticoids (GCs) are extensively used in the treatment of inflammatory skin diseases. However, their long-term use is often accompanied by severe and eventually irreversible adverse effects, with atrophy being the most important limitation. Currently, most non-clinical studies involve animal testing, so the results are not always representative of the situation in humans. The aim o...

BACKGROUND: The nail involvement in psoriasis is related to psoriatic arthritis and may represent a predictor of the disease. OBJECTIVES: To analyze, through nail clipping, clinically normal and dystrophic nails of patients with cutaneous psoriasis and psoriatic arthritis. METHODS: This is a cross-sectional multicenter study, conducted between August 2011 and March 2012. Patients were divid...

A 42-year-old woman with type 1 diabetes mellitus and a regular smoking habit (19 pack-years) presented with dysphagia, nausea and vomiting over the previous week, a er clindamycin treatment for infected diabetic foot ulcers. An esophagogastroduodenoscopy revealed sloughing reddish membranes in the distal esophagus, adjacent to intact healthy mucosa that were easily removed (Figs.1, 2). Histopa...

Cornoid lamellation is a specific disorder of epidermal maturation manifested by a vertical "column" of parakeratosis and is the hallmark of porokeratosis. The cornoid lamella is characterized by a ridgelike parakeratosis. We present 11 patients with solitary lesions of a distinct pattern of cornoid lamellation. The mean age at presentation clinically was 57 years; there were 9 men and 2 women....

The purpose of the present article is to present a 15 year-old patient with focal epithelial hyperplasia and to review the references on the subject-related etiological, pathological, diagnostic and treatment aspects. Focal epithelial hyperplasia is a rare human papilloma virus (HPV) related to oral lesion with very low frequency within our population. Surgical treatment with a biopsy was perfo...

Epidermolytic ichthyosis (EI) is a rare genodermatosis disorder. We report 39-year-old woman with EI, who presented generalized erythroderma since birth, followed by hyperkeratosis later in life. The physical examination revealed without blistering or erosion. histopathological studies parakeratosis and psoriasiform hyperplasia, significant epidermolysis. Sanger sequencing missense mutation—c.4...

be associated with porokeratosis,[8] this diagnosis was not considered owing to the lack of typical clinical features and histology of this condition. Authentic clinical and histologic features of Nekam’s disease are, respectively,[9] a facial seborrheic dermatitislike eruption with tiny confluent papules on the trunk and extremities in linear and reticulate arrays and an infundibulocentric and...

PATHOLOGY OF PSORIASIS. THE primary lesion is often a well defined pinhead size papule covered with fine silvery scales. The individual lesions spread at the periphery and often unite with other patches to form large plaques and sheets. Histological examination shows excessive growth of the epithelium with a badly formed horny layer (parakeratosis) and a downward growth of the interpapillary pr...