a novel approach to determine optimal sampling locations under parameter uncertainty in a water distribution system (wds) for the purpose of its hydraulic model calibration is presented. the problem is formulated as a multi-objective optimisation problem under calibration parameter uncertainty. the objectives are to maximise the calibrated model accuracy and to minimise the number of sampling d...

In certain manufacturing processes, product quality is characterized by spatial profiles, and such profiles are expected to meet specific shape requirements. As profile shapes are affected by process conditions, properly adjusted process variables are expected to help improve profile quality. This work aims to achieve desired shapes of profiles that are sensitive to the variation of noise facto...

Mathematical models are central in systems biology and provide new ways to understand the function of biological systems, helping in the generation of novel and testable hypotheses, and supporting a rational framework for possible ways of intervention, like in e.g. genetic engineering, drug development or treatment of diseases. Since the amount and quality of experimental 'omics' data continue ...