Hypercalcemia with concomitant elevation of serum parathyroid hormone (PTH) and PTH-related protein (PTHrP) levels was found in a patient with advanced gastric carcinoma and multiple liver metastases. The most common features are hypercalcemia associated with hypersecretion of PTHrP and physiological suppression of PTH secretion in the syndrome of humoral hypercalcemia of malignancy (HHM). Alth...

Atıf yazım şekli: How to cite: Kafadar MT, Kabalak B, Yalçın M, Tarini EZ. Parathyroid carcinoma: A rare cause of hyperparathyroidism in a geriatric patient underwent orthopedic surgery .. Arch Clin Exp Med. 2017;2(3):84-86. Abstract Parathyroid cancer is a rarely encountered disease which may accompany with hyperparathyroidism. It is hard to diagnose the disease before surgical treatment and t...

Next to smoking, obesity is the second leading preventable risk factor for cancer, but increasing rates of and overweight are estimated overtake smoking as cancer factor. Few research studies have investigated dysregulated endocrine metabolism dietary phosphate a potential mediating in association with cancer. Phosphate toxicity, accumulation excess body from metabolism, associated tumorigenesi...

BACKGROUND A new parathyroid hormone (PTH) species, the N-terminal PTH form (N-PTH), is distinct from intact human PTH of 84 amino acid residues [hPTH(1-84)] and is recognized in a 3rd-generation assay of "whole" PTH (wPTH; the 1-2 epitope) but not in a 2nd-generation assay of "total" PTH (tPTH; the 12-18 epitope). N-PTH usually represents <15% of wPTH but can be overproduced in severe primary ...

BACKGROUND Primary hyperparathyroidism (PHPT) is an endocrine disorder most commonly affecting women, suggesting a role for female hormones and/or their receptors in parathyroid adenomas. We here investigated the prolactin receptor (PRLr) which is associated with tumours of the breast and other organs. METHODOLOGY/PRINCIPAL FINDINGS PRLr expression was investigated in a panel of 37 patients w...

A 68-year-old woman with a history of parathyroidectomy of the left upper and right lower parathyroid gland for parathyroid carcinoma was admitted to our hospital for evaluation of fatigue and anorexia that lasted for 1 month. Blood chemistry was notable for hypercalcemia (14.1 mg/dL) and elevated parathyroid hormone (PTH) 1,652 pg/mL (0.35 to 5.50). Serum PTH-related peptide (PTHrP) level was ...

INTRODUCTION Cancer in the parathyroid gland is rare, but parathyroid cancer is occasionally seen in relation to genetic abnormalities. Due to a limited amount of evidence, the optimal handling of these cases is not clear. Furthermore, the presence of a malignant parathyroid tumor is rarely known at the time of the initial operation; therefore, re-operations are often necessary. The aim of this...

Hyperparathyroidism (HPT) is an endocrine disorder characterized by high secretion of parathyroid hormone. Brown tumor one the skeletal manifestations HPT. Its overall prevalence low (about 0.1%). Involvement facial bones extremely rare. The mandible involved in 4.5% cases. Primary HPT (PHPT)with vitamin D deficiency worsens clinical course. Parathyroid adenoma detected ectopic places with a ra...

thirty one patients with biologic and clinical diagnosis of hyperparathyroidism were submitted to thalium-technetium scan prior to exploration of the neck. scan findings were compared with the pathologic results. surgical exploration of the neck showed a parathyroid adenoma in 24 patients, parathyroid carcinoma in one patient, normal parathyroid in another patient and parathyroid hyperplasia in...