Integral membrane proteins are integrated cotranslationally into the membrane of the endoplasmic reticulum in a process mediated by the Sec61 translocon. Transmembrane α-helices in a translocating polypeptide chain gain access to the surrounding membrane through a lateral gate in the wall of the translocon channel [van den Berg B, et al. (2004) Nature 427:36-44; Zimmer J, et al. (2008) Nature 4...

slope stability analysis is an enduring research topic in the engineering and academic sectors. accurate prediction of the factor of safety (fos) of slopes, their stability, and their performance is not an easy task. in this work, the adaptive neuro-fuzzy inference system (anfis) was utilized to build an estimation model for the prediction of fos. three anfis models were implemented including g...

Gastric plexiform fibromyxoma (PF) is a rare mesenchymal tumor with a histologically distinctive multinodular pattern, dissimilar to conventional gastrointestinal stromal tumor (GIST). The current study presents one case of gastric PF, and one case of GIST with a platelet-derived growth factor receptor α (PDGFRA) mutation mimicking PF, and discusses their differential diagnoses. The two patient...

With the recent addition of anti-angiogenic agents to cancer treatment, the angiogenesis regulators in platelets are gaining importance. Platelet factor 4 (PF-4/CXCL4) and Connective tissue activating peptide III (CTAP-III) are two platelet-associated chemokines that modulate tumor angiogenesis, inflammation within the tumor microenvironment, and in turn tumor growth. Here, we review the role o...

The production of vascular permeability factor (PF) by certain strains of Pseudomonas aeruginosa has been demonstrated in rabbits injected intradermally with culture filtrates followed by intravenous injection with Pontamine Sky Blue 6BX. The dose-response curve was found to be rectilinear when lesion diameters, within the range of 10 to 20 mm, were plotted against log dose. Thus, PF in test fi...

The location of the Antarctic Polar Front (PF) was mapped over a 7-year period (1987–1993) within images of satellite-derived sea surface temperature. The mean path of the PF is strongly steered by the topographic features of the Southern Ocean. The topography places vorticity constraints on the dynamics of the PF that strongly affect spatial and temporal variability. Over the deep ocean basins...

Modulation of endothelial cell proliferation and cell cycle progression by the "chemokine" platelet factor-4 (PF-4) was investigated. PF-4 inhibited DNA synthesis, as well as proliferation of endothelial cells derived from large and small blood vessels. Inhibition by PF-4 was independent of the type and the concentration of stimuli used for the induction of endothelial cell proliferation. Inhib...

This study evaluated the effect of macro steel fiber (SF), micro glass fiber (GF) and micro polypropylene fiber (PF) in lightweight aggregate concrete, (LWAC) beams reinforced with glass fiber reinforced polymer (GFRP) bars. Firstly, concrete mixtures with different volume fractions of GF, PF and SF were tested up to compressive strength, then determine the optimum fiber content GF, PF and SF a...

OBJECTIVE Macrophages are the infiltrate components of tuberculous pleural effusion (TPE). This study is aimed at examining the role of different subsets of macrophages in pleural fluid (PF) and peripheral blood (PB) from patients with new onset TPE. METHODS The numbers of PB and PF CD163(+), CD206(+) and CD115(+) macrophages in 25 patients with new onset TPE and 17 healthy controls (HC) were...

OBJECTIVE To conduct separate exploratory factor analyses (EFA) and confirmatory factor analyses (CFA) of the Child Health Questionnaire-Parent Form 50 (CHQ-PF-50) with a sample of children and adolescents with chronic conditions and physically healthy children seen in a pediatric setting. METHOD Parents of 329 children with chronic conditions including cancer, epilepsy, recurrent headache, i...