Michaelis constants for MgATP with yeast hexokinase vary from 28 microM with D-mannose to above 4 mM for the slow ATPase reaction, with the different values reflecting the degree of synergism in binding of MgATP and the sugar substrate. The best substrates show the greatest synergism, but the correlation is not exact. Similar synergistic binding between MgADP or its methylene analogue and phosp...

Kinetic and binding studies involving a model DNA cytosine-5-methyltransferase, M.HhaI, and a 37-mer DNA duplex containing a single hemimethylated target site were applied to characterize intermediates on the reaction pathway. Stopped-flow fluorescence studies reveal that cofactor S-adenosyl-l-methionine (AdoMet) and product S-adenosyl-l-homocysteine (AdoHcy) form similar rapidly reversible bin...

A method has been developed for obtaining qualitative information about enzyme-catalyzed reactions by measuring the inhibitory effects of added substrates on positional isotope exchange rates. It has been demonstrated for ordered kinetic mechanisms that an increase in the concentration of the second substrate to add to the enzyme will result in a linear increase in the ratio of the chemical and...

Supramolecular carriers such as micelles can be used to noncovalently bind drug molecules for pharmaceutical applications. However, these carriers can fundamentally affect diffusion-based drug transport due to host-guest coupled diffusion. We report a ternary interdiffusion study on an ionic drug in aqueous micellar solutions. Specifically, high-precision Rayleigh interferometry was used to det...

Content addressable memory (CAM) is a type of solid-state memory in which data is provided as input and an operation is performed to returns the address as output. Unlike other memories (SRAM, DRAM), it performs the search operation in parallel on complete location at once, offered significant reduction in searching time. A ternary content addressable memory (TCAM) is a specialized CAM design f...

Diffusion coefficients of drug compounds are crucial parameters used for modeling transport processes. Interestingly, diffusion of a solute can be generated not only by its own concentration gradient but also by concentration gradients of other solutes. This phenomenon is known as multicomponent diffusion. A multicomponent diffusion study on drug-surfactant-water ternary mixtures is reported he...

A persistent challenge in membrane biophysics has been to quantitatively predict how membrane physical properties change upon addition of new amphiphiles (e.g., lipids, alcohols, peptides, or proteins) in order to assess whether the changes are large enough to plausibly result in biological ramifications. Because of their roles as general anesthetics, n-alcohols are perhaps the best-studied amp...

generalizing the concepts of -fuzzy (left, right, lateral) ideals, -fuzzy quasi-ideals and   -fuzzy bi (generalized bi-) ideals in ternary semigroups, the notions of -fuzzy (left, right, lateral) ideals, -fuzzy quasi-ideals and -fuzzy bi (generalized bi-) in ternary semigroups are introduced and several related properties are investigated. some new results are obtained.

The blocks of a balanced ternary design, BTD(V,B; ρ1, ρ2, R;K,Λ), can be partitioned into two sets: the b1 blocks that each contain no repeated elements, and the b2 = B − b1 blocks containing repeated elements. In this note, we address, and answer in some particular cases, the following question. For which partitions of the integer B as b1 + b2 does there exist a BTD(V,B; ρ1, ρ2, R;K,Λ)?

Let (ωn)0<n be the sequence known as Integer Sequence A047749 In this paper, we show that the integer ωn enumerates various kinds of symmetric structures of order two. We first consider ternary trees having a reflexive symmetry and we relate all symmetric combinatorial objects by means of bijection. We then generalize the symmetric structures and correspondences to an infinite family of symmetr...