Thank you very much for submitting your research manuscript for consideration to The EMBO Journal editorial office. All three referees judge the reported data as potentially interesting, but at the same time emphasize different aspects of the manuscript that needs at least some additional experimentation. Both refs#1 and #2 very much appreciate the cell culture aspect of the study, though reque...

ENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA Golpasandhagh L, Salehi P, Karimi B, Moghimipour E. Therapeutic effect of Ziziphus lotus honey on hard palate ulcers in rats. Medical Studies/Studia Medyczne. 2021;37(1):58-64. doi:10.5114/ms.2021.105002. APA Golpasandhagh, L., Salehi, P., Karimi, B., & Moghimipour, (2021). Medyczne, 37(1), 58-64. https://doi.org/...

Each clustering algorithm usually optimizes a qualification metric during its progress. The qualification metric in conventional clustering algorithms considers all the features equally important; in other words each feature participates in the clustering process equivalently. It is obvious that some features have more information than others in a dataset. So it is highly likely that some featu...

Integrin linked kinase (ILK) connects the ILK-Pinch-Parvin complex with integrin adhesion sites. Because of the functional relevance of integrin-linked signaling for endothelial cell (EC) biology, we have explored this pathway in Ilk(-/-) embryonic stem (ES) cells differentiated into ECs and vessel-like structures. We have focused in particular on the mechanistic relevance of ILK-Pinch-Parvin c...

Caenorhabditis elegans striated muscle cells attach to basement membrane and transmit the force of muscle contraction through integrin adhesion complexes. The cytoplasmic tail of β-integrin (PAT-3) is associated with a conserved four-protein complex that includes UNC-112 (kindlin), PAT-4 (integrin-linked kinase), PAT-6 (α-parvin/actopaxin), and UNC-97 (PINCH). The proper localization of UNC-112...

Astrocytoma as a primary tumour is the core item in this section in which, by considering a pedigree-based research approach, the involvement of Ataxia-Telangiectasia (AT) gene is investigated. The two-hit -hypothesis of Knudson’s model is given to clarify the process of tumourigenesis in retinoblastoma. Lack of any available data for any hit hypothesis in brain tumours was the reason why the t...