The hypothesis that saphenous vein patch angioplasty protects against early postoperative restenosis and thrombosis-occlusion was tested by comparing the clinical outcome and carotid artery status of 100 carotid endarterectomies with and 100 without saphenous vein patch angioplasty performed by a single surgeon over a 30-month period. The patient population, selection, perioperative management,...

Transition from malignant schwannoma to malignant triton tumor is analyzed in a case report on a patient with recurring cancers and suspected familial predisposition. It is hypothesized that rhabdomyoblastic differentiation, which distinguishes triton from schwannoma, might be attributable to Hedgehog-Patched pathway malfunctioning. Loss of one Patched gene allele was found in the tissue of adv...

Small-molecule inhibition of extracellular proteins that activate membrane receptors has proven to be extremely challenging. Diversity-oriented synthesis and small-molecule microarrays enabled the discovery of robotnikinin, a small molecule that binds the extracellular Sonic hedgehog (Shh) protein and blocks Shh signaling in cell lines, human primary keratinocytes and a synthetic model of human...

The maintenance of potholes is a long-standing problem. Previous studies focused on pothole patching materials and methods but not bonding at the interface joint. In this study, influence shape depth joint using two materials: hot mix asphalt (HMA) containing 5% (by volume) steel fiber (HMA+) was investigated. Slabs with circular square in middle different depths (35, 50 70 mm) were prepared. s...

Small-molecule inhibition of extracellular proteins that activate membrane receptors has proven to be extremely challenging. Diversity-oriented synthesis and small-molecule microarrays enabled the discovery of robotnikinin, a small molecule that binds the extracellular Sonic hedgehog (Shh) protein and blocks Shh signaling in cell lines, human primary keratinocytes and a synthetic model of human...

In this study, the fatigue behavior of composite patched and non-patched Al 5083 aluminum plates was numerically investigated. Aluminum with semi-circular notched (2, 3 4 mm long cracked) "V" (30°, 45° 60° angled) were used in analyzes. Mechanical properties plate, DP460 type adhesive produced by 3M [0°]8 glass fiber reinforced patch material for study. The Finite Element Method applied numeric...

Synapse development and neuronal activity represent fundamental processes for the establishment of cognitive function. Structural organization as well as signalling pathways from receptor stimulation to gene expression regulation are mediated by synaptic activity and misregulated in neurodevelopmental disorders such as autism spectrum disorder (ASD) and intellectual disability (ID). Deleterious...