PURPOSE The majority of pancreatic cancers overexpress mesothelin (MSLN), which contributes to enhanced proliferation, invasion, and migration. However, the MSLN regulatory network is still unclear. Here, we investigated the regulation of a panel of tumorigenic factors and explored the potential of MSLN-regulated miR-198 treatment in vivo. EXPERIMENTAL DESIGN The expression and functional reg...

Purpose: The majority of pancreatic cancers overexpress mesothelin (MSLN), which contributes to enhanced proliferation, invasion, and migration. However, the MSLN regulatory network is still unclear. Here, we investigated the regulation of a panel of tumorigenic factors and explored the potential of MSLNregulated miR-198 treatment in vivo. Experimental Design: The expression and functional regu...

An experimental apparatus was designed to study the non-shock initiation reaction evolution process of a HMX (cyclotetramethylenete-tranitramine)-based pressed PBX (Plastic Bonded Explosive)-A column under main constraint inertial mass explosive bulk, with strong bottom and circumferential confinements strength PMMA plate cover as threshold control internal pressure. The HMX-based PBX-A ignited...

Pbx genes are TALE class homeodomain transcription factors. They play diverse and important roles in organogenesis. To date, four Pbx members have been identified in vertebrate. The objectives of this study were to characterize and analyze the developmental functions of zebrafish pbx members. It is hoped that the information gained from this model system will facilitate in the understanding of ...

Atomistic molecular dynamics simulations were performed on a low molecular weight nitroplasticized Estane® mixture representative of the binder used in PBX-9501. Pressurevolume-temperature (PVT) behavior over a wide range of pressure and temperatures above the order-disorder temperature (ODT) of Estane was determined and represented with the empirical Tait and Sun equations-of-state. The effect...

In order to study the ignition process and response characteristics of cast polymer-bonded explosives (PBX) under action friction, HMX-based PBX were used carry out friction experiments at a 90° swing angle obtain critical loading pressure was 3.7 MPa. Combined with morphology characterization results PBX, temperature rise numerically simulated macro micro scale, judged. The accuracy numerical ...

The orphan nuclear receptor Ad4BP/SF-1 (adrenal 4 binding protein/steroidogenic factor 1) is essential for the proper development and function of reproductive and steroidogenic tissues. Although the expression of Ad4BP/SF-1 is specific for those tissues, the mechanisms underlying this tissue-specific expression remain unknown. In this study, we used transgenic mouse assays to examine the regula...

The Meis and Pbx genes encode for homeodomain proteins of the TALE class and have been shown to act as co-factors for other homeodomain transcription factors (Mann and Affolter, 1998. Curr. Opin. Genet. Dev. 8, 423-429). We have studied the expression of these genes in the mouse telencephalon and found that Meis1 and Meis2 display region-specific patterns of expression from embryonic day (E)10....

TALE (three amino acids loop extension) homeodomain transcription factors are required in various steps of embryo development, in many adult physiological functions, and are involved in important pathologies. This review focuses on the PREP, MEIS, and PBX sub-families of TALE factors and aims at giving information on their biochemical properties, i.e., structure, interactors, and interaction su...