the present work concerns on the investigation of the role of polyethylene glycols (pegs) as masking agent for amelioration of extraction-separation of la(iii), eu(iii) and er(iii) ions by the acidic extractant bis(2-ethylhexyl)phosphoric acid (dehpa). the studied solvent extraction system is based on the combination of chelating effect of dehpa in the organic phase on the one hand, and the bin...

Vitamin E D-alpha-tocopheryl polyethylene glycol succinate (TPGS) and polyethylene glycol are common excipients used in both preclinical and commercial formulations. In this paper, the phase diagrams of TPGS and polyethylene glycol 400 (PEG 400) in the presence of either water or ethanol were constructed. The effect of water and ethanol on the cloud point temperature of TPGS-PEG 400 mixtures wa...

Objective: Metoprolol succinate, which is used to treat cardiovascular disorders, a strong beta-1 adrenoreceptor blocker with cardio-selective effect but heavily metabolised in the liver during first pass. Our goal minimise hypertension by creating film of metoprolol succinate that dissolves quickly.
 Methods: films dissolve mouth were made utilising solvent casting technique. HPMC E5 was ...

Polycondensations were performed at 70 degrees C in bulk using physically immobilized lipase B from Candida antarctica (CAL-B) as catalyst. Study of copolymerizations between sebacic acid and PEG diols of differing Mn values (200, 400, 600, 1000, 2000, and 10 000) showed that PEG 400 and 600 were most reactive (DP(avg) up to about 6). Increasing the PEG diol chain length from 600 to 1000, 2000,...

The use of Acetyl Salicylic Acid (ASA) in the secondary prevention of cardio vascular diseases is well known. Orally administered ASA is rapidly metabolized to its principal metabolite Salicylic Acid (SA) in the gastrointestinal fluids, during absorption in the intestine and liver. ASA, and not its hydrolysis product SA, which exhibits antithrombotic activity. Transdermal delivery of acetylsali...

Identification of the usefulness of lipid-based formulations (LBFs) for delivery of poorly water-soluble drugs is at date mainly experimentally based. In this work we used a diverse drug data set, and more than 2,000 solubility measurements to develop experimental and computational tools to predict the loading capacity of LBFs. Computational models were developed to enable in silico prediction ...

The use of Acetyl Salicylic Acid (ASA) in the secondary prevention of cardio vascular diseases is well known. Orally administered ASA is rapidly metabolized to its principal metabolite Salicylic Acid (SA) in the gastrointestinal fluids, during absorption in the intestine and liver. ASA, and not its hydrolysis product SA, which exhibits antithrombotic activity. Transdermal delivery of acetylsali...

A generic form of vancomycin for I.V. infusion (MEEK) is more soluble and stable than the brand-name form of vancomycin hydrochloride (VCM) due to the addition of two inactive ingredients: D-mannitol and Macrogol400 (PEG400). The aim of the present study was to compare the nephrotoxicity of MEEK with that of brand-name VCM (S-VCM) and to analyze the pharmacokinetics of these preparations. Follo...

Magnetoelectric (Sr0.5Ba0.5Nb2O6)1?x?(CoFe2O4)x (x = 0.2–0.6) composites were prepared by a one-pot soft-chemistry synthesis using PEG400. Calcining at 700 °C resulted in nanocrystalline composite powders (dcryst. 24–30 nm) which sintered between 1050 and 1200 to ceramic bodies with relative densities up 98%. SEM investigations confirm the formation of ceramics 0–3 connectivity variable grain s...

We developed a disposable microfluidic chip which mimics the vapor diffusion method for exploring protein crystallization conditions but at nanoliter scale. This device exploits permeation of water through thin poly(dimethylsiloxane) (PDMS) layer separating droplets stored in and containing mixture proteins precipitants from an open reservoir. The chemical activity fixed by reservoir makes it p...