The inhibitory effects of intravenous secretion on the gastric acid responses to a meal and to pentagastrin were studied in seven duodenal ulcer patients.A test meal of 10% peptone adjusted to pH 5.0 was introduced into the stomach and the Fordtran and Walsh method was used to measure the gastric acid output by monitoring the rate at which a solution of 0.3 M sodium bicarbonate had to be added ...

Lower oesophageal sphincter pressures in healthy volunteers were measured by a rapid pull-through technique during intravenous infusion of the histamine H2-receptor antagonist, cimetidine. No consistent effects on sphincter pressure were observed which are liable to be of clinical importance. Serum gastrin concentrations during cimetidine infusion were measured by radioimmunoassay and showed no...

It has been shown that enhanced acid secretion can be suppressed in the rat by systemic administration of glucose. We have recently reported that enhancement of acid secretion as a result of pentagastrin was diminished by intragastric administration of D-glucose. Present study was designed to investigate whether intragastric D-glucose influences gastric acid secretion associated with carbachol ...

The response of the lower oesophageal sphincter (LOS) to intragastric instillation of protein was assessed in 10 healthy volunteers. Sphincter pressures were measured by a rapid pull-through technique and serum gastrin concentrations during each test were determined by radioimmunoassay. Despite stimulation of gastrin release by protein instillation, no significant change in LOS pressure was obs...

A novel carbamate prodrug 2 containing a pentagastrin moiety was synthesized. 2 was designed as a detoxified analogue of the highly cytotoxic natural antibiotic duocarmycin SA (1) for the use in a targeted prodrug monotherapy of cancers expressing cholecystokinin (CCK-B)/gastrin receptors. The synthesis of prodrug 2 was performed using a palladium-catalyzed carbonylation of bromide 6, followed ...

The effect of glucagon on the pressure inside the lower oesophageal sphincter in conscious human subjects and anaesthetized dogs was investigated using the continuous withdrawal method. Glucagon causes a decrease in sphincteric resting pressure in both man and dog and antagonizes the pentagastrin-induced pressure increase of the lower oesophageal sphincter. In experiments on isolated muscle str...

The electrical and motor activity was recorded from the duodenum in 16 conscious human subjects in resting conditions. The main electrical wave form variously known as the pace-setter potential or slow wave was constantly present and periodically accompanied by a second electrical trace consisting of rapid bursts of fast waves or action potentials which were related to motor waves. Secretin and...