Background: It is not yet known which types of Toll-like receptors (TLRs) are most effective in Helicobacter pylori (H. pylori) recognition. It is also not known which gastric zones have the most prominent roles in TLR-mediated bacterial recognition. The aim of this work was to analyze the expression of TLR2 and TLR4 in biopsy specimens from H. pylori-infected patients. Methods: Thirty-eight...

OBJECTIVES H. pylori infection has been associated with some autoimmune disorders. The aim of this study was to evaluate the serum concentrations of rheumatoid factor and anti-nuclear antibodies in H. pylori-infected peptic ulcer patients, H. pylori-infected asymptomatic carriers and a healthy control group. METHODS A Total of 100 H. pylori-infected peptic ulcer patients, 65 asymptomatic carr...

AIMS To investigate the association of cagA positivity and non-opsonic neutrophil activation capacity in wild-type Helicobacter pylori strains with peptic ulcer disease or chronic gastritis only. METHODS Helicobacter pylori were isolated from antral biopsies of 53 consecutive patients with chronic antral gastritis, of whom 24 had peptic ulcer disease endoscopically. The presence of cagA, a ma...

INTRODUCTION Limited data currently exists regarding the diagnostic indicators of peptic ulcer perforation for early detection among patients in Thailand. Delayed diagnosis and treatment for an ulcer can be life-threatening, resulting in shock or death. OBJECTIVE To determine the diagnostic indicators of peptic ulcer perforation. MATERIAL AND METHODS A cohort study was conducted in a tertia...

BACKGROUND & AIM The important role of IL-17 in inflammatory response to Helicobacter pylori (H. pylori) colonization has been indicated. We investigated the associations between gastro-duodenal diseases and polymorphisms of IL17A (rs2275913 G>A) and IL17F (rs763780 T>C). METHODS The study was performed in 548 subjects (363 controls and 185 peptic ulcer cases). The multiplex PCR-SSCP method w...

Peptic ulcer disease including both gastric and duodenal ulcer form a substantial part of patients seeking surgical opinion world-wide. The concept of acid in peptic ulcer disease, which was the basis of treatment of peptic ulcer was revolutionized by the discovery of H2-receptor antagonists, that led to the principle of acid suppression therapy for duodenal ulcer which followed decades of pref...

background: acute upper gi bleeding (ugib) is a common medical emergency situation. in the past years, important changes have taken place that might have influenced the incidence, etiology, and outcome for patients with acute ugib. the aim of this study was to determine current time trends in the incidence, management, and prognosis of patients with ugib in 14 years period in a region in center...

background: in developing countries primary antibiotic-resistance and poor compliance are the main causes of helicobacter pylori (hp) eradication failure of standard regimens. aim: to investigate eradication rate, patient's compliance and tolerability of a 1-wk azithromycin based quaruple therapy versus the 2-wk conventional therapy. materials and methods: a total of 129 hp-positive patients we...

background acute upper gastrointestinal bleeding (ugib) is a common medical emergency and is known as one of the main causes of mortality and morbidity. this research was conducted to study the causes and risk factors for ugib, in a referral center. methods in this cross sectional study, carried out in a one year period, all patients with acute ugib living in khorramabad city and surrounding ar...

background :the cag pathogenicity island includes a number of genes, including cytotoxin-associated protein a (caga) and vacuolatingcytotoxin (vaca) genotypes, which are associated with bacterial virulence. although the role of caga and vaca in the virulence of helicobacter pylori (h. pylori) is well-established in epidemiological studies, the relationship between the caga and vaca genotypes in...