background and aims. melatonin is a circulating hormone that is mainly released from the pineal gland. it possesses antioxidant, free-radical scavenging, and immune-enhancing properties. a growing number of studies reveal a complex role for melatonin in influencing various diseases, including diabetes and periodontal diseases. the aim of this study was to examine the possible links between sali...

Aims: This study aimed to determine the prevalence of endodontic-periodontal lesions (EPLs) and EPL grades 1–3 without root damage in patients with periodontitis according 2017 World Workshop on Classification Periodontal Peri-Implant Diseases.
 Methods: included 500 panoramic radiographs from Faculty Dentistry at University İstanbul Medipol. Each radiograph was evaluated by a calibrated i...

Palatogingival groove is a rare developmental anomaly involving the lingual surface of the maxillary incisor and resulting in severe endodontic and periodontal lesions. This case report describes a multidisciplinary approach for the combined management of the endodontic and periodontal problems for successful rehabilitation of the involved tooth. Cone-beam computed tomography (CBCT) helped in c...

Objective To compare the frequency and severity of periodontitis in patients with spondyloarthritis (SpA) with healthy control individuals, through the evaluation of clinical, serological and microbiological periodontal condition. Methods Patients with a diagnosis of SpA (n=78) and biological disease-modifying antirheumatic drug (bDMARD) naive fulfilling the Assessment of SpondyloArthritis in...

* Post-Doctoral Student, Department of Microbiology, Dental Research Institute, São Leopoldo-Mandic. ** Professor and Chairman, Department of Oral Pathology, School of Dentistry, University of São Paulo. *** Doctor of Dental Medicine, Private Practice, Fairhope, USA. **** Professor and Chairman, Department of Periodontology, School of Dentistry, State University of Campinas. ***** Doctor of Den...

BACKGROUND Host responses to periodontal disease include the production of different enzymes that are released by stromal, epithelial or inflammatory cells. There are important enzymes associated with cell injury and cell death like: aspartate and alanine aminotransferase (AST, ALT), lactate dehydrogenase (LDH), creatine kinase (CK), alkaline and acidic phosphatase (ALP, ACP), gama glutamyl tra...