Glaucoma is an optic neuropathy that affects the ganglion cell complex in all its components: cell bodies, dendrites, and axons, the dendritic arbor being the first one damaged. This is the reason why the thickness of the ganglion cell and internal plexiform layers can be taken into account as an early predictor of the glaucomatous changes, along with the retinal nerve fiber layer (RNFL) thickn...

PURPOSE To evaluate clinically activated retinal astrocytes and Müller cells (ARAM) regarding retinal sensitivity and retinal nerve fiber layer (RNFL) thickness in primary open-angle glaucoma (POAG). METHODS Central visual field (VF; i.e., retinal sensitivity) was measured with a custom-made macular pattern by microperimetry and correlated with the presence (ARAM+) or absence (ARAM-) of ARAM ...

OBJECTIVES To examine the late period retinal and choroidal alterations in the posterior pole of eyes that underwent primary suturing due to traumatic corneal perforation. MATERIALS AND METHODS This cross-sectional case series included 21 eyes of 21 patients. The fellow eyes served as the control group. Macular thickness, peripapillary retinal nerve fiber layer (RNFL) thickness, choroidal thi...

PURPOSE To evaluate a simplified method to measure peripapillary choroidal thickness using commercially available, three-dimensional optical coherence tomography (3D-OCT). METHODS 3D-OCT images of normal eyes were consecutively obtained from the 3D-OCT database of Korea University Medical Center On the peripapillary images for retinal nerve fiber layer (RNFL) analysis, choroidal thickness was...

PURPOSE To evaluate the reproducibility of peripapillary retinal nerve fiber layer (RNFL) thickness measurements in normal eyes and eyes with glaucoma using spectral domain optical coherence tomography (SDOCT). METHODS One eye of 79 normal and 72 glaucoma patients was analyzed. All patients underwent a complete ophthalmological examination, including visual acuity testing; intraocular pressur...

multiple sclerosis (ms) is the most prevalent disease caused by the inflammatory demyelinating process that causes progressive nervous system degeneration over the time. optical coherence tomography (oct) is a non-invasive optical imaging technology, which can measure the thickness of retinal nerve fiber layer as well as the diameter of the macula. the purpose of the study is evaluation oct fin...

PURPOSE To present a technique of ocular sectioning that enables continuous histologic measurements of peripapillary retinal nerve fiber layer (RNFL) thickness in a concentric ring around the optic disc, corresponding to similar regions measured by in vivo imaging techniques. METHODS Two pig eyes and two normal human eyes were processed using the "umbrella" technique, in which peripapillary c...

OBJECTIVE To perform in vivo analysis of retinal functional and structural parameters in healthy mouse eyes. ANIMAL STUDIED Adult C57BL/6 male mice (n = 37). PROCEDURES Retinal function was evaluated using pattern electroretinography (pERG) and the chromatic pupil light reflex (cPLR). Structural properties of the retina and nerve fiber layer (NFL) were evaluated using spectral-domain optica...

PURPOSE To investigate the relationship between retinal nerve fiber layer (RNFL) thickness and retinal pigment epithelium alterations in patients with advanced glaucomatous visual field defects. METHODS A consecutive, prospective series of 82 study eyes with primary open-angle glaucoma and advanced glaucomatous visual field defects were included in this study. All study participants underwent...