The peripheral nerves consist of sensory nerves that transmit somatic and visceral afferent information to the brain via the spinal cord and motor nerves that convey efferent outputs of the brain to effector organs such as skeletal muscles and glands. The nerve conduction velocities (NCV) of mammalian peripheral nerves range from 10 m/s to 150 m/s, depending on the type of information being tra...

Background and Objective: Approximately 45% of benign peripheral nerve sheath tumors (PNST) occur in head and neck regions. Malignant peripheral nerve sheath tumors (MPNST) are less common and only 815%of these tumors occur in head and neck region. In this study, we aimed at evaluating the demographic characteristics, pathologic findings, locations, main clinical presentations and family histor...

Malignant peripheral nerve sheath tumours (MPNSTs) may occur in any peripheral nerve. They are often found in the chest wall and the posterior mediastinum. On the other hand, primary pulmonary MPNST is extremely rare, and surgically treated cases have been reported. Here, we present 3 cases of primary MPNST originating from the pulmonary parenchyma who underwent surgery in our institution. We d...

INTRODUCTION Malignant peripheral nerve sheath tumors (MPNSTs) are sarcomas which originate from peripheral nerves or from cells associated with the nerve sheath, such as Schwann cells, perineural cells, or fibroblasts. Because MPNSTs can arise from multiple cell types, the overall appearance can vary greatly from one case to the next. This can make diagnosis and classification somewhat difficu...

Malignant peripheral nerve sheath tumors (MPNSTs) are rare, highly aggressive tumors capable of arising de novo or from preexisting benign neurofibromas or schwannomas. The treatment of choice is surgery. Trunk and extremities are the commonest sites involved. Malignant peripheral nerve sheath tumors are rarely encountered in head and neck region. Here, we report a patient with MPNST of lower l...

Malignant peripheral nerve sheath tumor (MPNST) usually arises in peripheral nerve sheath cells. The intraosseous location of MPNST is rare. Mandible is the most common site of bony involvement. Involvement of bones of the hand is quite unusual. We report a case of MPNST involving metacarpal bones of the left hand treated with surgery followed by adjuvant radiation and chemotherapy and review t...

By using the D2-40 antibody, we have observed podoplanin expression in Schwann cells and perineurial cells. Podoplanin expression has not been well characterized in peripheral nerve sheath tumors. Because neoplasms of neural crest lineage, including peripheral nerve sheath and melanocytic neoplasms, may share histologic and immunohistochemical characteristics, we evaluated podoplanin and S-100 ...