Chronic Lymphocytic Inflammation with Pontine Perivascular Enhancement Responsive to Steroids (CLIPPERS) syndrome is a rare neurological disorder uncertain etiology, pathogenesis and clinical course. Pittock et al. in 2010 first described this chronic inflammatory neurologic condition, which preferably affects the brainstem. There an infiltration cells of affected regions typical dotted curvili...

BACKGROUND Pulmonary hypertension (PH) causes elevated right ventricular (RV) systolic pressure, RV remodeling and finally RV failure to death. However, the mechanisms of RV remodeling in PH remain to be fully elucidated. METHODS AND RESULTS RV autopsy samples from 6 PH patients with RV failure against 3 age- and sex-matched controls were first examined. Next, RV remodeling in 2 mouse models ...

dried oleander leaves at single lethal dose of 110 mg/kg body weight were administered orally to fivenative female goats. clinical signs of toxicosis in goats began to appear about 1 hr after receiving theoleander and included abdominal pain, ruminal atony and tympany, frequent urination, bradycardia,tachycardia, tachyarrhythmia, depression, weakness and convulsive movement and death at the end...

Dried oleander leaves at single lethal dose of 110 mg/kg body weight were administered orally to fivenative female goats. Clinical signs of toxicosis in goats began to appear about 1 hr after receiving theoleander and included abdominal pain, ruminal atony and tympany, frequent urination, bradycardia,tachycardia, tachyarrhythmia, depression, weakness and convulsive movement and death at the end...

Background Tsutsugamushi disease is an acute, febrile, infectious disease caused by Orientia tsutsugamushi. Several studies investigating the histopathologic findings of eschars in tsutsugamushi disease reported leukocytoclastic vasculitis and neutrophil infiltration as the major findings. However, these findings may result from secondary changes following tissue necrosis. The histopathologic f...

At 4 to 6 weeks after intravenous infection with 2 X 10(4) CFU of dispersed Mycobacterium bovis bacilli (BCG), C3H/HeNCrIBR and C57BL/6NCrIBR mice exhibited a strong reaction to purified protein derivatives, as evaluated by the increase in footpad swelling at both 24 and 48 h after local antigenic challenge. However, histological studies of the footpad skin demonstrated a prominent perivascular...

AIM To establish whether ultrasound biomicroscope (UBM) is a helpful tool in locating the arterial segment responsible in patients with segmental attacks in giant cell arteritis METHODS The superficial temporal arteries of 19 patients with suspected giant cell arteritis were examined with the UBM before biopsy. RESULTS 20 specimens provided the histological proof of giant cell arteritis in ...

The human immunodeficiency virus (HIV) accesses the central nervous system (CNS) early during infection, leading to HIV-associated cognitive impairment and establishment of a viral reservoir. Here, we describe a dichotomy in inflammatory responses in different CNS regions in simian immunodeficiency virus (SIV)-infected macaques, a model for HIV infection. We found increased expression of inflam...

BACKGROUND Lobular keloid appears to be a consequence of hypertrophic inflammation secondary to ear piercings performed under unsterile conditions. We wish to understand the pathogenesis of lobular keloids and report operative outcomes with a literature review. METHODS A retrospective review identified 40 cases of lobular keloids between January, 2005 and December, 2010. Patient records were ...