Tissue-type plasminogen activator (tPA) is found in the intravascular space and in the central nervous system. The low-density lipoprotein receptor-related protein (LRP) is expressed in neurons and in perivascular astrocytes. During cerebral ischemia, tPA induces the shedding of LRP's extracellular domain from perivascular astrocytes, and this is followed by the development of cerebral edema. P...

perivascular epithelioid cell tumor (pecoma) is a rare mesenchymal tumor composed of immunohistochemically and histologically distinctive perivascular epithelioid cells. here, we report on the computed tomography (ct) and magnetic resonance imaging (mri) findings of ovarian pecoma with pulmonary metastasis. the tumor was visible as a multilocular hemorrhagic mass that encased the ovarian vessel...

Electronmicrographs of the choroid plexus from rats infected with Trypanosoma brucei rhodesiense showed that trypomastigotes from the perivascular spaces may penetrate and undergo multiple division in the ependymal cells which locally constitute the blood-brain barrier. Progressive degeneration of the ependymal cell liberates trypomastigotes back into the perivascular space, from which re-entry...

Astrocytic endfeet cover the entire cerebral vasculature and serve as exchange sites for ions, metabolites and energy substrates from the blood to the brain. They maintain endothelial tight junctions that form the blood-brain barrier (BBB) and release vasoactive molecules that regulate vascular tone. Malignant gliomas are highly invasive tumours that use the perivascular space for invasion and ...

AIM To establish whether ultrasound biomicroscope (UBM) is a helpful tool in locating the arterial segment responsible in patients with segmental attacks in giant cell arteritis METHODS The superficial temporal arteries of 19 patients with suspected giant cell arteritis were examined with the UBM before biopsy. RESULTS 20 specimens provided the histological proof of giant cell arteritis in ...

Abstract Introduction Emerging data from our group found longitudinal sleep variability within the Seattle Longitudinal Study was significantly associated with cognitive impairment and predicted 10-years downstream. While this supports a link between instability, aging, decline, mechanism linking these processes is unknown. MRI-visible perivascular space (PVS) burden putative marker of glymphat...