Cite this article: Williams AS (2016) Detection of Perivascular Adipose Tissue-Associated Macrophages by Zirconium-89 conjugated Imaging Probes – Utility for Diagnosis of Vascular Pathology During Inflammatory Arthritis? JSM Arthritis 1(1): 1003. *Corresponding author Anwen S Williams, Division of Infection and Immunity, School of Medicine, Cardiff University, United Kingdom, Tel: 4402920687092...

Inflammatory cross talk between perivascular adipose tissue and the blood vessel wall has been proposed to contribute to the pathogenesis of atherosclerosis. We previously reported that human perivascular (PV) adipocytes exhibit a proinflammatory phenotype and less adipogenic differentiation than do subcutaneous (SQ) adipocytes. To gain a global view of the genomic basis of biologic differences...

The perivascular adipose tissue (PVAT) is now recognized as an active contributor to vascular function. Adipocytes and stromal cells contained within PVAT are a source of an ever-growing list of molecules with varied paracrine effects on the underlying smooth muscle and endothelial cells, including adipokines, cytokines, reactive oxygen species, and gaseous compounds. Their secretion is regulat...

Introduction: Most of the blood vessels are surrounded by perivascular adipose tissue (PVAT) which could regulate vascular functions. Prostaglandin E2 (PGE2) released by PVAT could regulate vascular tone depending on which PGE2 receptors (EP) are expressed by the vessel (vasocontriction via EP1 / EP3, vasodilatation via EP2 / EP4 receptors). During vascular pathologies associated with inflammat...

Many types of cancer develop in close association with highly vascularized adipose tissues. However, the role of adipose pre-existing vascular beds on tumor growth and angiogenesis is unknown. Here we report that pre-existing microvascular density in tissues where tumors originate is a crucial determinant for tumor growth and neovascularization. In three independent tumor types including breast...