background and objective: nonsteroidal anti-inflammatory agents are the treatment of choice for ductal closure in premature newborn. this study evaluates early and late outcome, as well as the effectiveness of oral ibuprofen in the treatment of patent ductus arteriosus (pda) in premature infants. methods: in this clinical trial, all preterm infants below 37 weeks, with documentation of pda were...

Background: Periventricular hemorrhage (PVH) is common in early preterm neonates but much less common in term and late preterm neonates. The aim of this study was to identify the risk factors and outcomes of PVH in term and late preterm neonates in a tertiary care center in Upper Egypt. Methods: A total of 33 term and late preterm (≥ 34 weeks...

BACKGROUND The prophylactic administration of indomethacin reduces the frequency of patent ductus arteriosus and severe intraventricular hemorrhage in very-low-birth-weight infants (those with birth weights below 1500 g). Whether prophylaxis with indomethacin confers any long-term benefits that outweigh the risks of drug-induced reductions in renal, intestinal, and cerebral blood flow is not kn...

Periventricular-intraventricular hemorrhage (PV-IVH) is a major cause of neurological disabilities in preterm newborns. This study aimed to determine the perinatal factors associated with PV-IVH. We conducted a retrospective case-control study from preterm infants born at < or =34 weeks of gestation and admitted to Neonatal Intensive Care Units of Seoul National University Children's Hospital a...

OF LOW DOSE ASPIRIN : DETECTION AND MANAGEMENT Intracranial hemorrhage (ICH) in the fetus and newborn is a rare phenomenon with intra periventricular hemorrhage (IVH-PVH) being the most common type. The incidence of intracranial hemorrhage is higher in premature infants, occurring in approximately 25 45% of less than 32 weeks gestation or with a birth weight of less than 1,500g (Ref: 1, 2). Alt...

Abstract Background Cranial ultrasonography (CUS) has become an important tool to depict normal brain anatomy and detect the ischemic hemorrhagic injury patterns in high-risk neonates. The present study aimed assess utility of CUS diagnose spectrum preterm term neonates admitted neonatal intensive care unit (NICU) find association findings various adverse antenatal perinatal feto-maternal facto...

There is a growing body of evidence from clinical and epidemiologic studies that in utero exposure to infection plays an important role in the genesis of fetal or neonatal injury leading to cerebral palsy and chronic lung disease. Thus, after chorioamnionitis the incidence of immature neonates with periventricular white matter damage and periventricular or intraventricular hemorrhage is signifi...

The computed tomographic (CT) findings in six cases of neonatal herpes simplex encephalitis (HSE) are reviewed and compared with previous reports. The diagnoses were made on the basis of isolation of the virus from a brain biopsy specimen in one case, from cerebrospinal fluid in two cases, from tracheal aspirate in one case, and on clinical grounds in two cases. Five infants survived; all had s...