The goal of this study was to test the hypothesis that antioxidant estrogens, by a mechanism independent of the estrogen receptor, protect phospholipids residing in the plasma membrane of vascular smooth muscle cells from peroxidation and peroxidation-induced cell growth and migration. Peroxidation of membrane phospholipids was assessed by HPLC analysis of phospholipids extracted from rat aorti...

Effects of S-allylcysteine (SAC), an organosulfur compound of garlic, on circulatory lipid peroxidation and antioxidant levels were evaluated in N-nitrosodiethylamine (NEDA)-induced hepatocarcinogenesis in Wistar rats. Significantly elevated thiobarbituric acid reactive substances in the circulation of rats bearing carcinoma indicated the higher levels of lipid peroxidation which was accompanie...

Lipid peroxidation, hemolysis and thiol contents were studied in intact goat erythrocytes exposed to phenylhydrazine. An increase in lipid peroxidation, hemolysis and thiol content was observed after phenylhydrazine treatment of erythrocyte. Extracellular Ca potentiates the phenylhydrazine-induced lipid peroxidation and hemolysis of erythrocytes significantly. Ca does not influence much the thi...

The present study was designed to determine whether lipid peroxidation was associated with the impairment of the fertilizing capability of gilthead sperm after acute exposure to anionic surfactant Sodium Dodecyl Sulphate (SDS). Spawned eggs and sperm were collected from adult giltheads. Sperm suspensions (100,000,000 spermatozoa/mL) were dosed separately with different concentrations of SDS (0....

Lipid peroxidation is a primary cause of quality deterioration in meat and meat products. Free radical chain reaction is the mechanism of lipid peroxidation and reactive oxygen species (ROS) such as hydroxyl radical and hydroperoxyl radical are the major initiators of the chain reaction. Lipid peroxyl radical and alkoxyl radical formed from the initial reactions are also capable of abstracting ...

In this study, we investigated the role of nitric oxide metabolism and lipid peroxidation in patients with P. vivax malaria. The levels of nitrite and nitrate were analyzed using a procedure based on the Griess reaction and malondialdehyde levels which index of lipid peroxidation was determined by thiobarbituric acid reaction. The levels of nitrite/nitrate and malondialdehyde in patients were h...

Considering drug-induced lipid peroxidation as a possible mediator of drug-induced toxicity and exploiting the free radical scavenging action of antioxidants, the present study was designed to evaluate the antiperoxidative potential of morin on cyclophosphamide/flutamide-induced lipid peroxidation and also to evaluate the effect of morin on cyclophosphamide/flutamide-induced changes in choleste...

In this study, the effect of photosensitizers on lipid peroxidation in the retina was investigated. Porcine retinal homogenate was exposed to illumination from a fluorescent lamp with or without photosensitizers such as hematoporphyrin, rose bengal, and fluorescein for 60 min. The control, which was exposed to illumination without photosensitizers, did not show a significant increase in lipid p...

Ferritin and haemosiderin were shown, by the measurement of malondialdehyde production and loss of polyunsaturated fatty acids, to stimulate lipid peroxidation in liposomes. At pH 7.4 ascorbate was additionally required to achieve peroxidation; however, peroxidation occurred at pH 4.5 in the presence of iron-proteins alone. The damage was completely inhibited by the incorporation of chain-break...

The present study deals with exploration of lipid peroxidation induction capacity of cyclophosphamide, an anticancer drug, and in vitro evaluation of ascorbic acid as a suppressor of cyclophosphamide induced lipid peroxidation. Goat liver homogenate has been used as the lipid source. This evaluation was done by measuring the malondialdehyde, 4-hydroxy-2-nonenal, reduced glutathione and nitric o...