The announcement of the 1978 Lasker Award for Basic Medical Research has created two controversies. No one argues with the choice of the three winners-Solomon H. Snyder (Johns Hopkins University), John Hughes (Imperial College of Science and Technology. London), and Hans Kosterlitz (University of Aberdeen) —who were honored for the discovery of opiate receptors and enkephalins, opiate-like subs...

ABSTRAK
 Sekitar 80-90% pasien cystic fibrosis akan mengalami pancreatic insuffiency. Keadaan ini menyebabkan terjadinya malabsorpsi lemak dan protein berpengaruh pada status nutrisi dari pasien. Terapi insufficiency adalah dengan pemberian enzyme replacement therapy (PERT) untuk meningkatkan absorpsi juga fibrosis. Tujuan kajian sistematis mengetahui efikasi keamanan terapi PERT yang sehi...

This investigation presents a heuristic method for consumable resource allocation problem in multi-class dynamic Project Evaluation and Review Technique (PERT) networks, where new projects from different classes (types) arrive to system according to independent Poisson processes with different arrival rates. Each activity of any project is operated at a devoted service station located in a node...

The cellular composition of heterogeneous samples can be predicted using an expression deconvolution algorithm to decompose their gene expression profiles based on pre-defined, reference gene expression profiles of the constituent populations in these samples. However, the expression profiles of the actual constituent populations are often perturbed from those of the reference profiles due to g...

in this research, both resource allocation and reactive resource allocation problems in multi-server dynamic pert networks are analytically modeled, where new projects are expected to arrive according to a poisson process, and activity durations are also known as independent random variables with exponential distributions. such system is represented as a queuing network, where multi servers at ...

Of the mutationally defined rhythm genes in Drosophila melanogaster, period (per) has been studied the most. We have molecularly characterized three older per mutants-perT, perClk, and per04-along with a novel long-period one (perSLIH). Each mutant is the result of a single nucleotide change. perT, perClk, and perSLIH are accounted for by amino acid substitutions; per04 is altered at a splice s...