objective: gut–brain axis (gba) is very important in creation and modulation of gastrointestinal problems. aloe vera gel has gastroprotective properties. the purpose of this study was to evaluate the effect of aqueous extract of aloe vera leaves on the gastric acid secretion and brain and intestinal water content following acetic acid gastric ulcer induction. materials and methods: gastric ulce...

INTRODUCTION Polycythemia vera is a polyglobular myeloproliferative syndrome related to the mutation of multipotent hemopoietic stem cells. This case report describes a patient whose bladder tumor was associated with polycythemia vera and erectile dysfunction. The association of bladder neoplasia with polycythemia vera and erectile dysfunction has not previously been reported in the literature....

TET2 mutations are found in polycythemia vera and it was initially reported that there is a greater TET2 mutational burden than JAK2(V617F) in polycythemia vera stem cells and that TET2 mutations precede JAK2(V617F). We quantified the proportion of TET2, JAK2(V617F) mutations and X-chromosome allelic usage in polycythemia vera cells, BFU-Es and in vitro expanded erythroid progenitors and found ...

The plant Aloe vera has long been used in medicine, as dietary supplements and for cosmetic purposes. Aloe vera extracts are a rich source of polyphenols, such as aloin and aloe emodin and have shown a wide range of pharmacological properties, including anti-inflammatory and anti-cancer properties. The bioactive component aloe emodin has been reported to induce apoptosis in various cancer cell ...

removing the bacteria, including enterococcus faecalis, from the root canal is one of the important aims in endodontic treatment.we aimed to compare the antibacterial activity of chlorhexidine with two natural drugs. the antibacterial activities of three different propolis extracts (alcohol concentrations: 0, 15, 40%) and aloe vera gel on e. faecalis were compared using three methods: disk diff...

This is a preliminary study that explores the efficacy of Aloe vera gel formulation as a possible therapeutic agent in the prevention and management of polycystic ovary syndrome (PCOS). PCOS is recognized as the most common endocrinopathy of women. Increased androgen synthesis, disrupted folliculogenesis, and insulin resistance lie at the patho-physiological core of PCOS. Current therapy for su...

OBJECTIVES Aloe barbadensis miller or Aloe vera has been used for therapeutic purposes since ancient times with antifungal activity known to be amongst its medicinal properties. We conducted a pilot study to determine the antifungal properties of Malaysian Aloe vera leaf extract on otomycosis species including Aspergillus niger and Candida albicans. METHODS This laboratory-controlled prospect...

This study reports on the acute toxic effects of Aloe barbadensis Miller (Aloe vera) juice as well as high doses of the antioxidants vitamin C, vitamin E and TroloxTM (a water soluble vitamin E analogue) to the salt water crustacean Artemia franciscana. Aloe vera juice exposure resulted in acute toxicity, being capable of inducing mortality at dilutions as low as 4 % juice and having an LC50 at...

CONTEXT Megakaryocytes are the "hallmark" of Philadelphia chromosome-negative myeloproliferative neoplasms, such as essential thrombocythemia, polycythemia vera, and primary myelofibrosis; their morphology in correlation with Janus kinase 2 (JAK2 V617F) mutation as well as clinical and laboratory parameters remains unknown. OBJECTIVE To assess the morphology of megakaryocytes in bone marrow b...

Aloe vera is a perennial plant employed for medical, pharmaceutical and cosmetic purposes that is rich in amino acids, enzymes, vitamins and polysaccharides, which are responsible for its therapeutic properties. Incorporating these properties into a biopolymer film obtained from alginate and chitosan allowed the development of a novel wound dressing with antibacterial capacity and healing effec...