OBJECTIVE Intrahepatic cholestasis of pregnancy (ICP), characterized by skin pruritus and elevation of serum aminotransferase activity and bile acid concentration in the mother, is one of the most common liver disorders in pregnancy. It was proved that ICP might lead to fetal distress by triggering oxidative damage. Total bile acids (TBA) are an established marker for assessment of the severity...

Ovulation is induced by the preovulatory surge of luteinizing hormone (LH) that acts on the ovary and triggers the rupture of the preovulatory ovarian follicle by stimulating proteolysis and apoptosis in the follicle wall, causing the release of the mature oocyte. The pro-inflammatory cytokine tumor necrosis factor α (TNFα) and prostaglandin (PG) F2α (PGF2α) are involved in the control of ovula...

The aim of the present study was to assess the effect of gestational hypercholesterolaemia on the prostaglandin-induced uterine response in late pregnant mouse uterus. Gestational hypercholesterolaemia was developed in Swiss albino mice feeding a diet (HFHC diet) containing 1.25 % cholesterol, 0.5 % sodium cholate and 15 % fat for 6 weeks before mating and continuing up to the 19th day of gesta...

in this study, we aimed to investigate reproductive performance in estrus-induced zandi ewes treated with equine chorionic gonadotrophin (ecg) injection in combination with prostaglandin f2α (pgf2α)and gonadotrophin releasing hormone (gnrh) during non-breeding season. the estrous cycle was synchronized using controlled internal drug release (cidr) for 12 days. the ewes were randomly assigned to...

A modified GnRH+prostaglandin F2α (PGF2α) estrous synchronization protocol in combination with melengestrol acetate (MGA) was used at three locations using Angus (n=208), crossbred Bos indicus (n=294), and crossbred Bos indicus and Brahman cows (n=111) to evaluate the effectiveness of two PGF2α treatments to synchronize cows for artificial insemination (AI). On day 0 of the experiment all cows ...

In the present study, the question was addressed whether the feline placenta can synthesize prostaglandin F2α (PGF2α). The PGFS protein was elevated, particularly at 2.5-3 weeks of pregnancy compared to 7-8 (P < 0.05) and 8.5-9 weeks (P < 0.001). Transcripts for PGFS were significantly upregulated at 2.5-3 weeks of pregnancy and then gradually declined towards the end of gestation (P < 0.001). ...

− The objective of this work was to evaluate the use of intravaginal devices (IVD) for the control of reproductive events in swine. Sows at 112 days of pregnancy received an injection of PGF2α (control, n = 15) or PGF2α plus an IVD containing medroxyprogesterone acetate (IVD group, n = 14) for 48 hours. Sows initiated labor 27.7±1.6 and 82.3±3.8 h after PGF2α aplicaction, in control and treated...

nything that compromises sow milk yield would be expected to have a negative impact on piglet performance. Periparturient hypogalactia syndrome has been associated with endometritis.1 Most sow herds have some incidence of endometritis, with reported incidences ranging from 1.1%–37.2% for different herds.2 Recent interest has focused on the postpartum administration of prostaglandin F2α (PGF2α) ...

in this study, we aimed to investigate reproductive performance in estrus-induced zandi ewes treated with equine chorionic gonadotrophin (ecg) injection in combination with prostaglandin f2α (pgf2α)and gonadotrophin releasing hormone (gnrh) during non-breeding season. the estrous cycle was synchronized using controlled internal drug release (cidr) for 12 days. the ewes were randomly assigned to...

Physiological principals underlying synchronization of estrus identified 1) hormones naturally controlling the estrous cycle of cattle, 2) hormones commercially available, 3) mode of action of the hormones commercially available, and 4) when/how they might be used to manage estrus and breeding of beef cattle. The products available are progestogens (melengestrol acetate (MGA) and progesterone d...