The need for a gamma-emitting radioactive agent that will label platelets in plasma efficiently by a procedure that can be used uniformly in each laboratory is well recognized. A water soluble sodium salt of 2-Mercaptopyridine-A/-oxide (Merc) was evaluated that quantitatively chelated ln at a pH range of 0.7 to 7.4, and allowed greater than 80% incorporation of ln in platelets in plasma. This w...

Background: Ventilator management for children with hypoxemic respiratory failure may benefit from ventilator protocols, which rely on blood gases. Accurate non-invasive estimates for pH or PaCO2 could allow frequent ventilator changes to optimize lung protective ventilation strategies. If these models are highly accurate, they can facilitate the development of closed-loop ventilator systems. W...

In 1945, a method was described by Bonsnes and the writer (1) for the determination of urinary creatine which involved only the addition of picric acid to dilute urine solutions and heating in a boiling water bath. An 80 per cent conversion of creatine to creatinine was obtained. The method has now been modified to achieve 100 per cent conversion, on the basis of Clark and Thompson’s recent stu...

Nanocarriers can aid therapeutic agent administration to the lung, but controlling drug delivery from these systems after deposition in the airways can be problematic. The aim of this study was to evaluate if chemically mediated shell permeabilisation could help manipulate the rate and extent of nanocarrier drug release. Rifampicin was loaded into lipid shell (loading efficiency 41.0±11.4%, siz...