In recent years, the increasing use of synthetic dyes showed an increase of allergic contact dermatitis with tissues, food, pharmaceutical and cosmetic products. This paper describes a method for extracting quickly, efficiently and economically a natural dye the Nasunin, a purple anthocyanin. To assess the potential sensitizing effect on the skin, have been formulated and applied to the healthy...

widespread use of pharmaceuticals has resulted in mixture concentrations ranging from mg/l in effluent to µg/l concentrations in surface water. in a 2008 study, 13 pharmaceuticals, ranging in amounts from 0.0028 to 0.1757 µg/l, were identified in the tennessee river, usa and its tributaries. in order to address the need for risk assessment of environmentally relevant pharmaceutical mixtures, da...

OBJECTIVE Thimerosal, a mercury compound used as a preservative in vaccines administered during infancy, has been suspected to affect neuropsychological development. We compared the neuropsychological performance, 10 years after vaccination, of 2 groups of children exposed randomly to different amounts of thimerosal through immunization. METHODS Children who were enrolled in an efficacy trial...

Preclinical safety testing is one important step in the development of new medicines. The requirements of such testing are the subject of government regulations and may vary in details, but not in general principles, in different countries around the world. The approach to preclinical safety testing of new drugs is multidisciplinary and requires the expertise of members from many different fiel...

Carcinogenicity data of medicinal products for human use that have been authorised via the European centralised procedure (CP) between 1995 and 2009 were evaluated. Carcinogenicity data, either from long-term rodent carcinogenicity studies, transgenic mouse studies or repeat-dose toxicity studies were available for 144 active substances contained in 159 medicinal products. Out of these compound...

1253 Andrew Jack FiNaNcial TiMes UK doctors will be drawn into new efforts to boost cost effective prescribing in the next few months as part of a deal agreed this month between the government and industry. The newly revised pharmaceutical price regulation scheme (PPRS), designed to cut the overall NHS drug bill by about 5% in its five year life, will result in two initiatives to change current...

In this paper the authors disclose the result of a research carried out on two brothers whose parents were first cousins, being the gene transmitted by the father. The psychological test Wechsler Intelligence Scale of Children (WISC) was used in two occasions in order to assess the verbal and non-verbal skills. FRM and IRM were nine and eleven-year-old respectively, in the first examination, be...

Bulletin of the World Health Organization | February 2008, 86 (2) Nazma Begum has come to Gonoshasthya Kendra in Savar with stomach pains, travelling several miles from Dhamrai with her mother, Kajali Begum. “About four to five years ago we heard from our neighbours [that] this hospital was good and offered medical services at a low price,” says Begum, “so we made a ‘book’ [insurance card]. All...

BACKGROUND Most diabetic and hypertensive patients, principally the elderly, do not achieve adequate disease control and consume 5%-15% of annual health care budgets. Previous studies verified that pharmaceutical care is useful for achieving adequate disease control in diabetes and hypertension. OBJECTIVE To evaluate the economic cost and the incremental cost-effectiveness ratio (ICER) per qu...