[ABSTRACT] Objective: A brief summary of recent progress in pharmacodynamics and clinical studies of active components of a TCM herbal medicine-Coix Seed and its preparation-Kanglaite Injection. Method: Based upon the references published at home and abroad, a review has been written on the pharmacological actions of Coix Seed and its preparation-Kanglaite Injection as well as its clinical stud...

Opioid drugs are used to manage moderate severe pain in mammals and avian species. In dosing opioids for a particular species, it is optimal use regimens based on pharmacokinetics or pharmacodynamics studies conducted the same species as variability physiology among different may result differences drug pharmacodynamics. Unfortunately, typically extrapolated from closely related even mammals, w...

Semmelweis University, Department of Psychiatry and Psychotherapy and MTA-SE Neuropsychopharmacology and Neurochemistry Research Group of the Hungarian Academy of Sciences, Budapest, Hungary Semmelweis University, Department of Pharmacodynamics and MTA-SE Neuropsychopharmacology and Neurochemistry Research Group of the Hungarian Academy of Sciences, Budapest, Hungary University of Manchester, N...

Topiramate is a structurally novel anti-epileptic drug with at least 3 postulated mechanisms of action including: 1) potentiation of GABA responses, 2) impairment of AMPA/kainate glutamate receptors and 3) suppression of high frequency action potential firing. It has a favourable pharmacokinetic profile with rapid absorption, good bio-availability, linear pharmacokinetics, relatively long half-...

Reviewed by Piet H. van der Graaf In 2008 and 2010, the National Institute of General Medical Sciences of the National Institutes of Health sponsored two workshops that resulted in the 2011 white paper “Quantitative and Systems Pharmacology in the Post-genomic Era: New Approaches to Discovering Drugs and Understanding Therapeutic Mechanisms,” which is widely accepted to be a milestone marking t...

Complete List of Authors: Lee, Seung-Jin; Kyungpook National University, College of Veterinary Medicine, Laboratory of Veterinary Pharmacokinetics and Pharmacodynamics Birhanu, Biruk; Kyungpook National University, College of Veterinary medicine, Laboratory of Veterinary Pharmacokinetics and Pharmacodynamics Awji, Elias; Lovelace Respiratory Research Institute, COPD Program Kim, Myung-Hee; Kore...

Nanotechnology is the application of nanotechnology within medicine. An illustration of this is the use of pegylation as a means of modifying naturally occurring proteins which may have clinical applications, in order to improve the pharmacodynamics of the protein resulting in an effective medication. An example of this is pegylated interferon. The purpose of this review is to examine the chemi...

Aim – to analyze and summarize the published information related experimental andtherapeutic results of Unithiol application in Ukraine.Conclusion. As seen from analysis therapeutic results, furtherextended investigation pharmacodynamics seems reasonable thelight its effective administration as an antidote, a metabolitotropic drug thetherapy other pathological conditions.

Our knowledge of the pharmacodynamics of cannabinoids, that is, “the study of the biochemical and physiologic effects of drugs and their mechanisms of action” (The Merck Manual), has considerably increased within the past decade due to the detection of an endogenous cannabinoid system with specific receptors and their endogenous ligands. THC (D9-tetrahydrocannabinol), the main source of the pha...