نتایج جستجو برای: pharmacological technique

تعداد نتایج: 683340  

2015
Bruno Hay Mele Valentina Citro Giuseppina Andreotti Maria Vittoria Cubellis

A promising strategy for the treatment of genetic diseases, pharmacological chaperone therapy, has been proposed recently. It exploits small molecules which can be administered orally, reach difficult tissues such as the brain and have low cost. This strategy has a vast field of application. In order to make drug development as fast as possible, it is important to exploit drug repositioning. We...

2015
Julie Foucquier Mickael Guedj

Combination therapies exploit the chances for better efficacy, decreased toxicity, and reduced development of drug resistance and owing to these advantages, have become a standard for the treatment of several diseases and continue to represent a promising approach in indications of unmet medical need. In this context, studying the effects of a combination of drugs in order to provide evidence o...

Journal: :The British journal of ophthalmology 1977
A C Molteno M M Van Rooyen R S Bartholomew

The implant design, surgical technique, and pharmacological methods of controlling bleb fibrosis, used to treat neovascular glaucoma, are described, together with the results of 14 operations performed on 12 eyes.

Journal: :British journal of sports medicine 1997
N A Evans

In addition to the pharmacological side effects of anabolic steroids, complications may also result from the injection technique used in self administration. Two cases are presented where anabolic steroid injections resulted in knee joint sepsis and radial nerve palsy.

Journal: :The Journal of biological chemistry 2009
Syed M Noorwez Reddy Ranjith K Sama Shalesh Kaushal

The lectin chaperone calnexin (Cnx) is important for quality control of glycoproteins, and the chances of correct folding of a protein increase the longer the protein interacts with Cnx. Mutations in glycoproteins increase their association with Cnx, and these mutant proteins are retained in the endoplasmic reticulum. However, until now, the increased interaction with Cnx was not known to incre...

2015
J Read K Gibson C Cartwright C Shiels C Dowrick M Gabbay

OBJECTIVE To explore the non-pharmacological correlates of the perceived effectiveness of antidepressants (ADs), thereby enhancing understanding of the mechanisms involved in recovery from depression while taking ADs. METHOD An online survey was completed by 1781 New Zealand adults who had taken ADs in the previous 5 years. RESULTS All 18 psychosocial variables measured were associated with...

Journal: :The Journal of biological chemistry 2003
Syed M Noorwez Vladimir Kuksa Yoshikazu Imanishi Li Zhu Sławomir Filipek Krzysztof Palczewski Shalesh Kaushal

Protein conformational disorders, which include certain types of retinitis pigmentosa, are a set of inherited human diseases in which mutant proteins are misfolded and often aggregated. Many opsin mutants associated with retinitis pigmentosa, the most common being P23H, are misfolded and retained within the cell. Here, we describe a pharmacological chaperone, 11-cis-7-ring retinal, that quantit...

Journal: :International journal of psychophysiology : official journal of the International Organization of Psychophysiology 2006
Torsten Baldeweg Davina Wong Klaas E Stephan

Impairment in mismatch negativity (MMN) generation is a robust biological marker of schizophrenia. Understanding the physiological and pharmacological processes involved in its generation may therefore advance our understanding of this complex disorder. The present study tested if acute administration of nicotine modulates human auditory sensory memory as measured with MMN. ERP responses to ton...

Journal: :Drug and alcohol dependence 2015
Larissa J Maier Severin Haug Michael P Schaub

OBJECTIVES This study examined the relationship between stress, self-efficacy, self-medication, and pharmacological neuroenhancement (PNE) in the Swiss general population. METHODS Using the largest Swiss Internet panel, a sample of 10,171 employees and students (unweighted N=10,084) aged 15-74 years was recruited and asked to complete a self-administered online survey. The data were weighted ...

2017
Victoria Foster Elicia Collins Han Dong Grace Nteff Laura Pinkney

This study examined perceived learning barriers to and strategies for teaching clinical pharmacology to undergraduate nursing students. The purposes of this study were to discuss barriers and strategies for teaching clinical pharmacology to undergraduate nursing students and compare those findings to student evaluation responses. This study used a comparative, cross-sectional design and examine...

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