Abstract Nonsteroidal anti-inflammatory drugs (NSAIDs) and coxibs are traditional medicines for the treatment of inflammation, yet associated with serious side effects. Hence, need discovering novel compounds valuable clinical benefits is great importance. In this study, 18 derivatives p-nitrophenyl hydrazones were docked against COX-2, 5-LOX, H+/K+ ATPase, followed by predicting their drug-lik...

The aromatic polyketones 3a-d are versatile compounds for the synthesis of the multi-1,2,3-selenadiazole aromatic derivatives 1a-d. The preparation starts with the reaction between the multi-bromomethylene benzene derivatives 2a-d and 4-hydroxy- acetophenone to give compounds 3a-d which are transformed through the reaction with semicarbazide hydrochloride or ethyl hydrazine carboxylate into the...

Two new macrocyclic hydrazone Schiff bases were synthesized by reaction of succindihydrazide and adipdihydrazide with acetylacetone. Hydrazones have been characterized by elemental analyses and IR, mass, (1)H NMR, and (13)C NMR spectral data. Hydrazones have been studied by liquid-liquid extraction towards the s-metal ions (Li(+), Na(+), and K(+)) and d-metal ions (Cu(2+) and Cr(3+)) from aqueo...

An efficient method for the Citric acid-catalyzed synthesis of hydrazones Schiff base using 2,4-dinirtophenyl hydrazine. We have synthesized a series of hydrazones using 2,4-dinirtophenyl hydrazine as a source of amine and substituted aromatic aldehydes and aromatic ketones as a carbonyl source. Synthesized compounds were characterized by FT-IR techniques. Synthesis of above hydrazones using ci...

Metal-free, intermolecular hydroaminations are performed upon heating aryl acetylenes and MeNHNH(2) at 140 degrees C, with preferential formation of the linear, "anti-Markovnikov" hydrazones.

The N-heterocyclic carbene-catalyzed [3 + 3] cyclocondensation of bromoenals and hydrazones is developed to give the corresponding chiral 4,5-dihydropyridazones in good yields with excellent enantioselectivities.

Photochemical reactions of imines, hydrazones, oximes and related compounds provides an efficient access to radical intermediates in the synthesis heterocycles.

substituted schiff bases (hydrazones) 5a-j have been prepared from the starting material 2-chloro pyridine-3-carboxylic acid 1 by a sequence of reactions like reaction with 2-amino-6-nitro benzothiazole (ullamann condensation), thionyl chloride, hydrazine hydrate and different aromatic aldehydes. on cyclocondensation of 5a-j with thioglycolic acid in dry 1,4-dioxane furnished desired compounds ...