BACKGROUND Ephedrine, unlike phenylephrine, has a dose-related propensity to depress fetal pH during spinal anesthesia during cesarean section. A low arterial umbilical cord pH has a strong association with neonatal mortality and morbidity. The purpose of this retrospective study was to investigate influences of vasopressor change on Apgar scores and adverse neonatal outcomes in cesarean sectio...

equally in ENT and ophthalmic theatres. However, those recommendations relating to phenylephrine concentration and dose appear to be speci®cally relevant to ENT surgery. The weakest commercially available ocular phenylephrine preparation is 2.5%. It is doubtful whether a 10-fold reduction in phenylephrine concentration would result in clinically useful pupillary dilatation. Had our surgeons use...

Hepatocytes isolated from the livers of fed rats were used for a cQmparative study of the effects of phenylephrine, vasopressin and glucagon on gluconeogenesis and Qn enzymes of glycogen metabolism. When hepatocytes were incubated in the presence of Ca2 , phanylephrine stimulated gluconeogenesis from pyruvate less than did glucagon, but, in contrast with this hormone, it did not affect the acti...

Adenosine has been shown to exert direct antihypertrophic effects on the heart, and plasma adenosine levels have been shown to be elevated in patients with heart failure. It has therefore been proposed that endogenously synthesized adenosine may function as a cardiac antihypertrophic factor. The present study was aimed to determine whether the adenosine system is altered in a potential adaptive...

AIMS The aim of this study was to examine the effects of bisoprolol (BIS), a selective beta1-adrenoceptor antagonist without partial agonistic activity, on noradrenaline- and phenylephrine-evoked venoconstriction in man using the dorsal hand vein compliance technique. METHODS Twelve healthy male volunteers participated in three weekly experimental sessions. Subjects were allocated to treatmen...

The outflow changes in 26 eyes were measured during the course of a positive provocative test with pilocarpine and phenylephrine. Three separate patterns of response occurred: (1) One dose of pilocarpine and phenylephrine produced an acute attack with a large reduction in outflow. (2) The first dose of pilocarpine and phenylephrine produced a fall in pressure and increase in outflow. The second...

Type IV hypersensitivity eye reactions have been described after the administration of the sympathomimetic agent phenylephrine. We report the case of an atopic woman who developed nasal congestion and discharge, dysphagia, and dyspnea 1 hour after the administration of Stopcold pills and Disneumon Pernasal nasal spray for otitis. The same symptoms reappeared after the accidental administration ...

Phenylephrine exerted a positive chronotropic and inotropic effect on isolated, spontaneously beating, atria of reserpinised rabbits. Addition of phenoxybenzamine and phentolamine resulted in a depression of control contractile amplitude. Practolol, however, was devoid of this effect. The positive inotropic response to phenylephrine was significantly antagonised by all the three blockers used, ...

Phenylephrine in concentrations of either 2.5% or 10% is widely used as a mydriatic agent in ophthalmic surgery. Its potential cardiovascular effects are seldom recorded as ophthalmic surgery is not usually monitored by an anaesthetist. A prospective randomised double blind study was carried out in 89 consecutive cases of uncomplicated cataract surgery in the presence of an anaesthesiologist en...

The alpha-adrenergic agonist phenylephrine was found to inhibit protein labelling from [3H]valine in isolated liver cells. This effect is only observable under conditions of partial Ca2+ depletion and in cells displaying maximal rates of protein labelling, i.e. cells isolated from fed animals or from starved animals when incubated in the presence of alanine. The ability of phenylephrine to inhi...