Pheochromocytomas are catecholamine-producing tumors that can occur in the context of von Hippel-Lindau syndrome (VHL) and multiple endocrine neoplasia type 2 (MEN2). Pheochromocytomas in these two syndromes differ in histopathological features, catecholamine metabolism, and clinical phenotype. To further investigate the nature of these differences, we compared the global protein expressions of...

background: chemical exposure is a major health problem globally. poison control centers (pccs) play a leading role both in developed and developing countries in the prevention and control of poisonous chemical exposures. in this study, we aimed to assess the current state of pccs in pakistan and highlight capacity building needs in these centers. methods: a cross-sectional survey of the two re...

The Planck Catalogue of Compact Sources (PCCS) is the catalogue of sources detected in the first 15 months of Planck operations, the “nominal” mission. It consists of nine single-frequency catalogues of compact sources, both Galactic and extragalactic, detected over the entire sky. The PCCS covers the frequency range 30–857 GHz with higher sensitivity (it is 90 % complete at 180 mJy in the best...

Collections are at the heart of every program. Modern programming languages have acknowledged this fact by including increasingly better expression mechanisms for manipulating collections of data and objects. When existing objects are selected as elements of collections, often there is an implicit intention that those objects, by means of having been selected, take on new roles. Such is the cas...

OBJECTIVE Phaeochromocytomas (PCCs) are widely known for their clinical unpredictability. This study intends to define predictive plasma markers for their variable postoperative behaviour. Furthermore, the diagnostic accuracy of these plasma tests was determined. DESIGN AND METHODS A retrospective correlative study was performed in a series of 83 operated and four autopsied patients in order ...

Prior Converted Croplands (PCCs) are historic wetlands that were transformed (drained, dredged, filled or leveled) to support production of agricultural crops prior to “Swampbuster” provisions of the 1985 Food Security Act. Our research suggests that PCCs can substantially reduce nitrate export from agricultural watersheds in the region, an ecosystem function shared with natural and restored we...

CONTEXT AND OBJECTIVE Despite extensive molecular investigation of adrenal pheochromocytomas, no information is available on their molecular and mismatch repair (MMR) profiles by topographic compartments. DESIGN AND SETTING Microdissected samples from the peripheral and internal zones of 143 pheochromocytomas from a referral hospital (95 sporadic and 48 associated with multiple endocrine neop...

UNLABELLED Paragangliomas and pheochromocytomas are genetically heterogeneous diseases. The purpose of this study was to determine the sensitivity and specificity of PET with 3,4-dihydroxy-6-(18)F-fluoro-L-phenylalanin ((18)F-DOPA) for the detection and staging of pheochromocytomas/paragangliomas. Furthermore, we assessed whether the genotypes of pheochromocytomas and paragangliomas correlate w...

In recent years analyses of dependence structures using copulas have become more popular than the standard correlation analysis. Starting from Aas, Czado, Frigessi, and Bakken (2009) regular vine pair-copula constructions (PCCs) are considered the most flexible class of multivariate copulas. PCCs are involved objects but (conditional) independence present in data can simplify and reduce them si...

OBJECTIVE Poison control centers (PCCs) routinely collaborate with emergency departments (EDs) to provide care for poison-exposed patients. During this process, a significant amount of information is exchanged between EDs and PCCs via telephone, leading to important inefficiencies and safety vulnerabilities. In the present work, we identified and assessed a set of data standards to enable a sta...