Work from this laboratory has established that brain cephalin (1, 2) is a mixture of three different phosphatides; namely, phosphatidyl serine (3), phosphatidyl ethanolamine, and diphosphoinositide. In a preliminary note (4) it has been shown that diphosphoinositide has inositol metadiphosphate’ as a constituent. The present paper contains detailed proof of this statement and reports some other...

1. Histamine release by antigen from three sensitized rat tissues is potentiated by phosphatidyl serine (PS). The effect is greatest with isolated peritoneal cells. Phosphatidyl inositol, ethanolamine, choline and phosphatidic acid are inactive.2. PS greatly increases the rate of antigen-induced histamine release and only slightly prolongs the duration of the release process.3. PS shows a conce...

Multifunctional nanomaterials showed graet advantages in drug delivery. Folic acid (FA) binding protein, a glycosyl phosphatidyl inositol anchored cell surface receptor for folate, is overexpressed in several human tumors, whereas it is highly restricted in normal tissues. Therefore, in this study, FA, polyethylene glycol (PEG), and Fe3O4 nanoparticles multifunctionalized short multiwall carbon...

A 51 year old man with Waldenström's macroglobulinaemia presented with a malabsorptive syndrome related to extensive small bowel lymphangiectasia caused by immunoglobulin accumulation. The patient's plasma had strong lupus anticoagulant activity and the IgM lambda paraprotein displayed specificity for the negatively charged phospholipids phosphatidyl serine and phosphatidyl inositol, as well as...

Effectors are pathogen-encoded proteins that are thought to facilitate infection by manipulation of host cells. Evidence showing that the effectors of some eukaryotic plant pathogens are able to interact directly with cytoplasmic host proteins indicates that translocation of these proteins into host cells is an important part of infection. Recently, we showed that the flax rust effectors AvrM a...

Microelectrophoresis was found to be a rapid method for studying the interaction between aminoglycoside antibiotics and liposomes prepared from acid phospholipids. The ability to cause charge reversal of liposomes prepared from phosphatidyl inositol was ranked in the order neomycin greater than gentamicin greater than tobramycin greater than amikacin greater than kanamycin greater than ribostam...

The inositol-containing phosphatides of soy beans have been the subject of a number of investigations (l-7) since 1939 when Klenk and Sakai (8) first reported the presence of inositol in soy bean phosphatides. Previous work at the Northern Regional Research Laboratory (3) has shown that the alcohol-insoluble portion of soy bean phosphatides can be separated into two inositol-containing fraction...