Quinoline-3-carboxamides are an essential class of drug-like small molecules that known to inhibit the phosphatidylinositol 3-kinase-related kinases (PIKK) family kinases. The quinoline nitrogen is shown bind hinge region kinases, making them competitive inhibitors adenosine triphosphate (ATP). We have previously designed and synthesized quinoline-3-carboxamides as potential ataxia telangiectas...

The transforming protein of polyoma virus, middle T antigen, associates with two cellular enzymes, pp60c-src, a protein tyrosine kinase, and a phosphatidylinositol kinase that forms phosphatidylinositol 3-phosphate. The formation of a ternary complex of these proteins is essential for complete transformation and maximal tumor induction by the virus. A mutant virus encoding an altered middle T p...

Accumulation of amyloid beta and its toxicity are the common features in Alzheimer’s disease. Autophagy plays an important role development progression disease by causing selfdegradation accumulated from neurons. Glycitin has been found as major phytochemical constituent soybean, which shows neuroprotective function The present study aims to explore glycitin clearance reducing neuronal cells. h...

Coriander (Coriandrum sativum L.) is classified in the Apiaceae family and used as an herb. leaf has been reported to possess various health functions. Here, we report anti-allergic effect of aqueous coriander extract (ACLE). ACLE with 1.0 mg/mL or higher concentration significantly inhibited degranulation RBL-2H3 cells a concentration-dependent manner no cytotoxicity. suppressed increase intra...

The addition of cyclic AMP (cAMP) to Saccharomyces cerevisiae cyr1 mutant cells resulted in an increase in the rate of phosphatidylinositol synthesis at the expense of phosphatidylserine synthesis. The decrease in phosphatidylserine synthesis correlated with the down regulation of phosphatidylserine synthase activity by cAMP-dependent protein kinase phosphorylation. The increase in phosphatidyl...

Piperine is a dietary alkaloid with huge pharmacological importance and was first isolated from pepper extract. It has been reported anti-cancer, anti-amoebic, anti-mycobacterial, anti-mutagenic, anticonvulsant, anti-asthmatic, immunomodulatory, anti-inflammatory anti-oxidant activity. Therefore, the current investigation designed to unveil anticancer effects of piperine molecule against human ...

Previous studies in our laboratory showed that human adenoviruses use integrins αvß3 and αvß5 to promote internalization. In recent studies, we investigated the mechanisms by which αv integrins promote viral uptake by cells. We found that several signaling molecules, including focal adhesion kinase and phosphatidylinositol-3-kinase, become phosphorylated during interaction of the adenovirus pen...

MPS: Muscle Protein Synthesis; mTORC1: Mammalian Target of Rapamycin Complex 1; mTOR: Mammalian Target of Rapamycin; PI3K: Phosphatidylinositol-3 Kinase; PIP2: Phosphatidylinositol4,5-biphosphate; PIP3: Phosphatidylinositol-3,4,5-triphosphate; PDK: Phosphoinositide-dependent Kinase; 5’-TOP: 5’ terminal oligopyrimidine; eIFs: Eukaryotic Initiation Factors; GAP: GTPase Activating Protein; BCAAs: ...

Phosphatidylinositol-3-kinase pathway is constitutively activated in chronic lymphocytic leukemia mainly due to microenvironment signals, including stromal cell interaction and CXCR4 and B-cell receptor activation. Because of the importance of phosphatidylinositol-3-kinase signaling in chronic lymphocytic leukemia, we investigated the activity of the NVP-BKM120, an orally available pan class I ...