fetuin-a is a phosphorylated glycoprotein produced by liver.it by binding to calcium ion inhibits ectopic calcium deposition and protects vascular calcification. fetuin-a acts as a multifactorial protein and its role has been documented from brain development to bone remodeling and immune function, regulation of insulin activity, hepatocyte growth factor activity and inhibition lymphocyte blast...

Objective(s):  The role of the Apoptosis repressor with caspase recruitment domain (ARC) in apoptosis and in certain hypertrophic responses has been previously investigated, but its regulation of Endothelin-1 induced cardiac hypertrophy remains unknown. The present study discusses the inhibitory role of ARC against endothelin–induced hypertrophy. Results:In present study Endothelin treated car...

Tau is one of several types of microtubule-associated proteins (MAPs), responsible for the assembly and stability of microtubule networks that is present only in neurons and predominantly localized in axons which its functions are tightly regulated by phosphorylation. Via as yet unknown mechanisms, tau becomes hyperphosphorylated and accompanies with neuronal degeneration, loss of synapses...

Significance The functional diversity of MAPKs is dependent on differential selection substrates for phosphorylation. Nevertheless, the mechanisms assisting to maintain substrate specificity in plants are not known. Our study shows that WRKY33, a pathogen-responsive MPK3/6 substrate, SUMOylated response pathogen-associated molecular patterns and pathogen signals. SUMOylation mediates WRKY33 pho...

Abstract Background Tristetraprolin (TTP) family proteins contain conserved tandem CCCH zinc-finger binding to AU-rich elements and C-terminal NOT1-binding domain. TTP is phosphorylated extensively in cells, its mRNA destabilization activity regulated by protein phosphorylation. Methods We generated an antibody against phospho-Serine316 located at the site examined phosphorylation LPS-stimulate...

Starch synthesis is an elaborate process employing several isoforms of starch synthases (SSs), branching enzymes (SBEs) and debranching (DBEs). In cereals, some biosynthetic can form heteromeric complexes whose assembly controlled by protein phosphorylation. Previous studies suggested that SSIIa forms a trimeric complex with SBEIIb, SSI, in which SBEIIb phosphorylated. This study investigates t...

The ribosome is subjected to post-translational modifications, including phosphorylation, that affect its biological activity. Among ribosomal elements, the P-proteins undergo phosphorylation within C terminus, element which interacts with trGTPases or ribosome-inactivating proteins (RIPs); however, role of has never been elucidated. Here, we probed function on interaction RIPs using P1-P2 dime...

Oxidative stress is defined as an imbalance between the antioxidant defense system and production of reactive oxygen species (ROS). At low levels, ROS are involved in regulation redox signaling for cell protection. However, upon chronical increase oxidative stress, damage occurs, due to protein, DNA lipid oxidation. Here, we investigated modifications myofilament proteins, their role modulating...