In this study, confined impinging liquid jets are used to produce nanoparticles of carbamazepine (CBZ). The effect of operating parameters, such as the kind of solvent,CBZ concentration, flow rate of solution and antisolvent on particle size, are experimentally investigated. The Scanning Electron Micrograph (SEM) photomicrographs show that nanodrug with smaller particle is achievable by usi...

Implicit solvent models are powerful tools in accounting for the aqueous environment at a fraction of the computational expense of explicit solvent representations. Here, we compare the ability of common implicit solvent models (TC, OBC, OBC2, GBMV, GBMV2, GBSW, GBSW/MS, GBSW/MS2 and FACTS) to reproduce experimental absolute hydration free energies for a series of 499 small neutral molecules th...

Nanogels are nano-sized three-dimensional polymer networks engineered by physical or chemical cross-linking of individual polymer chains loaded with drugs and nucleotides that swells in a good solvent

ibuprofen solid dispersions were prepared by the solvent and fusion-solvent methods using polyethylene glycol (peg), polyvinylpyrrolidone (pvp), eudragit rs po, eudragit rl po and hydroxypropylmethylcellulose (hpmc) as carriers to improve physicochemical characteristics of ibuprofen. the prepared solid dispersions were evaluated for the flowability, solubility characteristics and dissolution be...

The molecular associations in the binary mixtures of (methanol/solvent), (ethanol/solvent) and (propanol/solvent) were studied using NMR, FTIR and VLE data at different temperatures. The activity coefficients as the most important quantities representing the mixture deviation form ideal behavior were evaluated by using various association models to express the physical and chemical contribution...