In the thymus, immature T cells are positively and negatively selected by multiple interactions between their Ag receptors (TCRs) and self MHC/peptide complexes expressed on thymic stromal cells. Here we show that in the milieu of negative selection on physiological self class II MHC/peptide complexes (Abwt), a single class II/peptide complex AbEp52-68 positively selects a number of TCRs with v...

Artificial neural networks (ANNs) have become common data driven tools for modeling complex, nonlinear problems in science and engineering. Many previous applications have relied on gradient-based search techniques, such as the back propagation (BP) algorithm, for ANN training. Such techniques, however, are highly susceptible to premature convergence to local optima and require a trial-and-erro...

In the title compound, C(9)H(11)BrN(2)O(5), the ribofuran-ose ring has a C2-exo, C3-endo twist configuration and is attached to the uracil unit via a β-N(1)-glycosidic bond. The crystal structure is stabilized by two inter-molecular O-H⋯O inter-actions and one inter-molecular N-H⋯O inter-action.

Inhaltsverzeichnis Einleitung 2 1 Theoretische Grundlagen 4 1.1 Tief inelastische ep-Streuung und

The title compound, C(6)H(12)O(6), also known as d-Tagatose, occurs in its furanose and pyranose forms in solution, but only the α-pyran-ose form crystallizes out. In the crystal, the molecules form hydrogen bonded chains propagating in [100] linked by O-H⋯O interactions. Further O-H⋯O bonds cross-link the chains.

The title compound, C(19)H(26)O(8)S, has been synthesized from 2,3:4,5-di-O-isopropyl-idene-β-d-fructopyran-ose. The absolute configuration of the fused ring is confirmed by anomalous dispersion effects in the diffraction measurement. The six-membered β-fructopyran-ose ring has a twist-boat conformation with the two five-membered rings trans to each other. In the crystal, inter-molecular non-cl...

Gene therapy constitutes a promising strategy for the treatment of osteoarthritis (OA). We assessed the use of electroporation (EP) of non-viral gene vectors, and compared its efficacy with that of adeno-associated virus (AAV) vectors. EPand AAV-mediated delivery of human interleukin-1 receptor antagonist (hIL-1Ra) was localized performed in the joints of rats following induction of OA. mRNA le...

INTRODUCTION To compare the efficiency of Epley (Ep) and Sémont-Toupet (ST) repositioning maneuvers and to evaluate postmaneuver restriction effect on short-term vertigo and dizziness after repositioning maneuvers by an analog visual scale (VAS) in benign positional paroxysmal vertigo (BPPV). MATERIAL AND METHODS 226 consecutive adult patients with posterior canal BPPV were included. Patients...

Several decarbonised polygeneration systems exploiting carbon capture and storage (CCS) or CO2 reuse technologies for the conversion of primary resources into clean fuels, chemicals, electricity and heat are systematically analysed for techno-economic feasibility. A process simulation, energy integration and economic analysis based approach has been employed to arrive at a representative set of...

Anandamide can be metabolized by cyclooxygenase-2 to produce prostaglandin E(2) (PGE(2)) ethanolamide. The purpose of this study was to investigate the pharmacology of this novel compound. Radioligand binding experiments in membranes from human embryonic kidney cells transfected with PGE(2) receptor subtypes EP(1), EP(2), EP(3), and EP(4) revealed that PGE(2) ethanolamide has pK(i) values of 5....