In the title compound, C(21)H(25)NO(3)·C(2)H(4)O(2), the piperidone ring adopts a chair conformation. The two meth-oxy groups are nearly coplanar with the aromatic rings to which they are attached. The dihedral angle between the two aromatic rings is 60.9 (2)°. There are two short intra-molecular N-H⋯O contacts. The crystal packing is stabilized by inter-molecular O-H⋯N and C-H⋯O inter-actions.

In the title compound, C(33)H(26)F(2)N(2)O(2), the piperidone ring adopts a half-chair conformation and the pyrrolidine rings adopt half-chair and envelope conformations. The two benzene rings make dihedral angles of 29.58 (5) and 76.33 (5)° with the mean plane of the 1,2-dihydro-acenaphthyl-ene unit. An intra-molecular O-H⋯N hydrogen bond helps to stabilize the mol-ecular structure. In the cry...

In the title compound, C(22)H(19)NOS(2), the thio-phene rings form angles of 69.74 (18) and 65.56 (16)° with the benzene ring. The piperidone ring adopts a half-chair conformation due to the presence of the conjugated ketone systems. Both thio-phene rings are disordered over two orientations [occupancies of 0.758 (2)/0.242 (2) and 0.588 (2)/0.412 (2)] at 180° from one another. In the crystal, w...

In the title compound, C(32)H(30)N(2)O(7), the piperidone ring adopts a chair conformation and the five-membered ring of the dihydro-indenone ring system adopts an envelope conformation. Intra-molecular O-H⋯N and C-H⋯O hydrogen bonds occur. The dihedral angle between the two hydr-oxy-subsituted methoxy-phenyl rings is 71.12 (5)°. In the crystal structure, mol-ecules are connected by inter-molec...

In the title compound, C(38)H(36)N(3)O(2)S(2)·CH(2)Cl(2), the 2-oxindole ring is almost planar (r.m.s. deviation = 0.032 Å), the pyrrolidine ring adopts a twist conformation and the piperidone ring exists as a chair. Three short C-H⋯O intra-molecular contacts occur. In the crystal, mol-ecules are linked by C-H⋯O and C-H⋯N inter-actions. The dichloro-methane solvent mol-ecule is disordered over ...

Some methoxy-, hydroxyl-, pyridyl-, or fluoro-substituted 3,5-bis(arylidene)-4-piperidones (BAPs) could reduce inflammation and promote hepatoma cell apoptosis by inhibiting activation of NF-?B, especially after introduction trifluoromethyl. Herein, a series trifluoromethyl-substituted BAPs (4-30) were synthesised the biological activities evaluated. We successfully found most potential 16, whi...

In the title compound, C(33)H(28)N(2)O(2)·0.25C(2)H(6)O·0.6H(2)O, the piperidone ring adopts a chair conformation and the pyrrolidine ring adopts an envelope conformation. The dihedral angle between the two phenyl rings is 70.83 (16)°. One of the N atoms of the organic mol-ecule is disordered over two positions in a 0.52 (4):0.48 (4) ratio and the two solvent mol-ecules are partially occupied a...

In the title compound, C(37)H(32)N(2)O(3), an intra-molecular O-H⋯N hydrogen bond generates a five-membered ring, producing an S(5) motif. The piperidone ring adopts a half-chair conformation. The two fused pyrrolidine rings have similar envelope conformations. The interplanar angles between the benzene rings A/B and C/D are 75.68 (7) and 30.22 (6)°, respectively. In the crystal structure, adja...

An efficient synthetic route towards tosyl-protected (2S)-phenyl-3-piperidone, a common intermediate for many drugs, has been developed in 5 steps in 54% yield from biomass derived furfural. The synthetic utility of the piperidone core structure was demonstrated with the synthesis of a NK1 receptor antagonist.