This analysis evaluated the effects of deferasirox on liver iron concentration in moderate and heavily iron-overloaded patients with β-thalassaemia from the ESCALATOR trial (n = 231). Mean liver iron concentrations (LIC) decreased significantly from 21.1 ± 8.2 to 14.2 ± 12.1 mg Fe/g dry weight (dw) at 2 yr (P < 0.001) in patients with LIC ≥ 7 mg Fe/g dw at baseline; patients with LIC < 7 mg Fe/...

Urinary metabolites of organophosphate (OP) and pyrethroid (PYR) pesticides biomarkers effects were studied in a population (n=40) residing an important agricultural area the province Córdoba (Argentina). Detection frequencies (DF) higher than 85% observed for pirimiphos (2-diethylamino-6-methylpyrimidin-4-ol –DEAMPY-, median 7.5 ?g/g creatinine, DF: 100%), parathion (p-nitrophenol, 0.99 chlorp...

The aim of this study was to investigate levels of polychlorinated biphenyls (marker and dioxin-like congeners), polycyclic aromatic hydrocarbons (EPA 15 + 1), polybrominated diphenyl ethers (14 predominant congeners) and pesticides (74 compounds) in various cold-pressed vegetable oils. Poppy seed oil, rapeseed oil, sesame seed oil, pumpkinseed oil, hempseed oil, linaire oil, borage oil and eve...

Four strains of Aedes aegypti (L.), one from Cuba and three from Venezuela, were bioassayed for susceptibility to eight insecticides, including the organophosphates, temephos, malathion, fenthion, pirimiphos methyl, and chlorpyrifos, and the pyrethroids, deltamethrin, lambda cyhalothrin and cypermethrin, S, S, S,-tributyl phosphorotrithioate and piperonyl butoxide were used as synergists to ass...

or solid particles with a size in the range of 10–1000 nm. Depending upon the method of preparation, nanoparticles, nanospheres or nanocapsules can be obtained. Controlled release and particle degradation characteristics can readily be modulated by the choice of matrix constituents1. Efficacy of Chrysosporium tropicum, a pathogenic fungus mediated silver and gold nanoparticles was reported agai...

A new method of producing butyrylcholinesterase (BChE) preparations, stable in storage and use, has been proposed. The BChE preparation is the enzyme co-immobilized with 0.2 M 5-5′-dithiobis (2-nitrobenzoic acid) starch or gelatin gel. All experimental preparations retain activity for at least 300 d. based on gel show higher but lower sensitivity to toxicants tested this study compared gel-base...

Background and Aims: Humans animals have daily contact with various chemicals, including food additives, pesticides, antibiotics, other veterinary drugs, xenobiotics. Pesticide exposure causes many health disorders. Mixed to pesticides is an important issue for human environmental health. Methods: In this study, we determined the cytotoxicity of chlormequat pirimiphos-methyl, glyphosate, tebuco...