The transcription factor Pit-1/Pou1f1 regulates GH and prolactin (PRL) secretion in the pituitary gland. Pit-1 expression and GH regulation by Pit-1 have also been demonstrated in mammary gland. However, no data are available on the role of Pit-1 on breast PRL. To evaluate this role, several human breast cancer cell lines were transfected with either the Pit-1 expression vector or a Pit-1 small...

Pavlovian-to-instrumental transfer (PIT) is an effect whereby a classically conditioned stimulus (CS) enhances ongoing instrumental responding. PIT has been extensively studied with appetitive conditioning but barely at all with aversive conditioning. Although it's been argued that conditioned suppression is a form of aversive PIT, this effect is fundamentally different from appetitive PIT beca...

theoretical review of ‘mining pit lakes’ indicates that like natural lakes such lakes display a huge diversity. they are typically in a non-equilibrium state with respect to their surroundings. hence, at the decommissioning phase of mining operation a detailed technical study are required on different aspects of such created water bodies considering its morphometry, geology, hydrology, water qu...

In the 1990s numerous winter orographic cloud seeding experiments were conducted over Utah’s Wasatch Plateau. Several previously published case studies successfully documented the physical response in clouds and precipitation to ground-based seeding with silver iodide and liquid propane. A previously unpublished case study that shows additional evidence of positive seeding effects is presented ...

in order to study the effect of sowing methods and seeding rates on fodder yield and some agronomic characters of nikshahri alfalfa ecotype, an experiment was conducted in a split plot arrangement in randomized complete block design with four replications in the field of agricultural and natural resources center of baluchistan in iranshahr region. in this study, sowing methods: hand spread, 12 ...

introduction: meningioma is a benign and slowly-growing tumor that is responsible for 20% of brain neoplasms. it can be accompanied by some genetic disorders such as neurofibromatosis type 2 and is more common among women. as a space occupying lesion, it produces a wide range of signs and symptoms by compressing the adjacent and underlying tissues in the brain. trauma and viruses are possible e...

PiT-1 protein is a transmembrane sodium-dependent phosphate (Pi) transporter. PiT-1 knock out (KO) embryos die from largely unknown causes by embryonic day (E) 12.5. We tested the hypothesis that PiT-1 is required for endocytosis in the embryonic yolk sac (YS) visceral endoderm (VE). Here we present data supporting that PiT-1 KO results in a YS remodeling defect and decreased endocytosis in the...

Four cloud-seeding cases over southern Idaho during the 2010/11 winter season have been simulated by the WeatherResearch and Forecasting (WRF)model using the coupled silver iodide (AgI) cloud-seeding scheme that was described in Part I. The seeding effects of both ground-based and airborne seeding as well as the impacts of model physics, seeding rates, location, timing, and cloud properties on ...

Ultimate limits of an open pit, which define its size and shape at the end of the mine’s life, is the pit with the highest profit value. A number of algorithms such as floating or moving cone method, floating cone method II and the corrected forms of this method, the Korobov algorithm and the corrected form of this method, dynamic programming and the Lerchs and Grossmann algorithm based on grap...