Protein kinase C (PKC) is a family of serine/threonine protein kinases involved in many cellular responses. Although the analysis of PKC activity in many systems has provided crucial insights to its biologic function, the precise role of different isoforms on the differentiation of normal hematopoietic progenitor cells into the various lineages remains to be investigated. The authors have asses...

Protein kinase C (PKC) is a family of serine/threonine protein kinases involved in many cellular responses. Although the analysis of PKC activity in many systems has provided crucial insights to its biologic function, the precise role of different isoforms on the differentiation of normal hematopoietic progenitor cells into the various lineages remains to be investigated. The authors have asses...

The cellular decoding of receptor-induced signaling is based in part on the spatiotemporal activation pattern of PKC isoforms. Because classical and novel PKC isoforms contain diacylglycerol (DAG)-binding C1 domains, they may compete for DAG binding. We reasoned that a Ca2+-induced membrane association of classical PKCs may accelerate the DAG binding and thereby prevent translocation of novel P...

Protein kinase (PK)C , PKC , and PKC comprise the conventional PKC isoform subfamily, which is thought to regulate cardiac disease responsiveness. Indeed, mice lacking the gene for PKC show enhanced cardiac contractility and reduced susceptibility to heart failure. Recent data also suggest that inhibition of conventional PKC isoforms with Ro-32-0432 or Ro-31-8220 enhances heart function and ant...

Drugs that target protein kinase C (PKC) are now being evaluated in patients with non-small cell lung cancer (NSCLC), but the role of PKC in NSCLC cells remains unclear. We report here that NSCLC cell lines show enhanced phosphorylation and altered expression of specific PKC isoforms compared with normal lung epithelial cells. PKC inhibition variably increased apoptosis, with rottlerin, a PKC i...

In this paper, we present a new class of public key cryptosystems by modifying K(XII)SE(1)PKC [1], referred to as K(XIII)SE(1)PKC, and a particular class of K(XIII)SE(1)PKC, Kp(XIII)SE(1)PKC. We show that K(XIII)SE(1)PKC would improve both the coding rate and the security, compared with K(XII)SE(1)PKC. We also show that Kp(XIII)SE(1)PKC realizes the coding rate of exactly 1.0. In a sharp contra...

Abstract The mechanism by which the combination of fluorine and aluminum (FA) cause learning memory impairment is still unclear. Curcumin a yellow polyphenol extracted from rhizome plant curcuma longa linn, has anti-apoptotic antioxidant functions; studies have shown that PKC-NMDAR pathway plays an important role in process cell apoptosis. Based on above, we designed vitro study curcumin apopto...

Although activation of protein kinase C (PKC) and mitogen-activated protein kinases (MAPKs) are known to play crucial roles in the manifestation of cardioprotection, the spatial organization of PKC signaling modules in naïve and protected myocardium remains unknown. Based on evidence that mitochondria are key mediators of the cardioprotective signal, we hypothesized that PKC and MAPKs interact,...

We previously reported that some ATP competitive protein kinase C (PKC) inhibitors are either competitive or uncompetitive inhibitors with respect to substrate peptides. In this report, we demonstrate how the interactions between PKC and inhibitors change PKC activation kinetics. A substrate competitive inhibitor, bisindolylmaleimide I, targets activated PKC and stabilizes PKC in the activated ...